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10.1073/pnas.1515558112 http://scihub22266oqcxt.onion/10.1073/pnas.1515558112 C4653152!4653152!26504196     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (45): 13898-903 Nephropedia Template TP {{tp|p=26504196|t=2015. Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity |pdf=|usr=}}{{26504196}} gab.com Text Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26504196 #FOAvip A recent outbreak of chikungunya virus in the Americas has caused more than one million infections in humans. The reemergence of this virus has become a major threat to public health due to a lack of available vaccines and antiviral drugs. We determined the cryo-EM structures of chikungunya virus particles complexed with two of the most potent human antibody fragments described in a previous study. Both antibodies neutralized the virus by stabilizing the position of the viral surface glycoproteins, which blocks the exposure of the glycoprotein fusion loops required to initiate viral entry into the cytoplasm of a target cell. Twit Text FOAVip Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26504196 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26504196 #FOAvip English Wikipedia <ref>{{Cite pmid|26504196}}</ref> Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity #MMPMID26504196 Long F; Fong RH; Austin SK; Chen Z; Klose T; Fokine A; Liu Y; Porta J; Sapparapu G; Akahata W; Doranz BJ; Crowe JE; Diamond MS; Rossmann MG Proc Natl Acad Sci U S A 2015[Nov]; 112 (45): 13898-903 PMID26504196show ga A recent outbreak of chikungunya virus in the Americas has caused more than one million infections in humans. The reemergence of this virus has become a major threat to public health due to a lack of available vaccines and antiviral drugs. We determined the cryo-EM structures of chikungunya virus particles complexed with two of the most potent human antibody fragments described in a previous study. Both antibodies neutralized the virus by stabilizing the position of the viral surface glycoproteins, which blocks the exposure of the glycoprotein fusion loops required to initiate viral entry into the cytoplasm of a target cell. äCryo-EM structures elucidate neutralizing mechanisms of anti-chikungun(epmc).pdf DeepDyve Pubget Overpricing