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10.1016/j.ajo.2015.08.032 http://scihub22266oqcxt.onion/10.1016/j.ajo.2015.08.032 C4653116!4653116!26343007     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Ophthalmol 2015 ; 160 (6): 1269-1275.e1 Nephropedia Template TP {{tp|p=26343007|t=2015. Retinal Architecture in ?RGS9- and ?R9AP-Associated Retinal Dysfunction (Bradyopsia) |pdf=|usr=}}{{26343007}} gab.com Text Retinal Architecture in RGS9- and R9AP-Associated Retinal Dysfunction (Bradyopsia) JO: Am J Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=26343007 #FOAvip Purpose: To characterize photoreceptor structure and mosaic integrity in subjects with ?RGS9- and R9AP-associated retinal dysfunction (bradyopsia) and compare to previous observations in other cone dysfunction disorders such as oligocone trichromacy. Design: Observational case series. Methods: setting: Moorfields Eye Hospital (United Kingdom) and Medical College Wisconsin (USA). study population: Six eyes of 3 subjects with disease-causing variants in ?RGS9 or R9AP. main outcome measures: Detailed retinal imaging using spectral-domain optical coherence tomography and confocal adaptive-optics scanning light ophthalmoscopy. Results: Cone density at 100 ?m from foveal center ranged from 123 132 cones/mm2 to 140 013 cones/mm2. Cone density ranged from 30 573 to 34 876 cones/mm2 by 600 ?m from center and from 15 987 to 16,253 cones/mm2 by 1400 ?m from center, in keeping with data from normal subjects. Adaptive-optics imaging identified a small, focal hyporeflective lesion at the foveal center in both eyes of the subject with RGS9-associated disease, corresponding to a discrete outer retinal defect also observed on spectral-domain optical coherence tomography; however, the photoreceptor mosaic remained intact at all other observed eccentricities. Conclusions: Bradyopsia and oligocone trichromacy share common clinical symptoms and cannot be discerned on standard clinical findings alone. Adaptive-optics imaging previously demonstrated a sparse mosaic of normal wave-guiding cones remaining at the fovea, with no visible structure outside the central fovea in oligocone trichromacy. In contrast, the subjects presented in this study with molecularly confirmed bradyopsia had a relatively intact and structurally normal photoreceptor mosaic, allowing the distinction between these disorders based on the cellular phenotype and suggesting different pathomechanisms. Twit Text FOAVip Retinal Architecture in RGS9- and R9AP-Associated Retinal Dysfunction (Bradyopsia) ????Am J Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=26343007 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26343007 #FOAvip English Wikipedia <ref>{{Cite pmid|26343007}}</ref> Retinal Architecture in ?RGS9- and ?R9AP-Associated Retinal Dysfunction (Bradyopsia) #MMPMID26343007 Strauss RW; Dubis AM; Cooper RF; Ba-Abbad R; Moore AT; Webster AR; Dubra A; Carroll J; Michaelides M Am J Ophthalmol 2015[Dec]; 160 (6): 1269-1275.e1 PMID26343007show ga Purpose: To characterize photoreceptor structure and mosaic integrity in subjects with ?RGS9- and R9AP-associated retinal dysfunction (bradyopsia) and compare to previous observations in other cone dysfunction disorders such as oligocone trichromacy. Design: Observational case series. Methods: setting: Moorfields Eye Hospital (United Kingdom) and Medical College Wisconsin (USA). study population: Six eyes of 3 subjects with disease-causing variants in ?RGS9 or R9AP. main outcome measures: Detailed retinal imaging using spectral-domain optical coherence tomography and confocal adaptive-optics scanning light ophthalmoscopy. Results: Cone density at 100 ?m from foveal center ranged from 123 132 cones/mm2 to 140 013 cones/mm2. Cone density ranged from 30 573 to 34 876 cones/mm2 by 600 ?m from center and from 15 987 to 16,253 cones/mm2 by 1400 ?m from center, in keeping with data from normal subjects. Adaptive-optics imaging identified a small, focal hyporeflective lesion at the foveal center in both eyes of the subject with RGS9-associated disease, corresponding to a discrete outer retinal defect also observed on spectral-domain optical coherence tomography; however, the photoreceptor mosaic remained intact at all other observed eccentricities. Conclusions: Bradyopsia and oligocone trichromacy share common clinical symptoms and cannot be discerned on standard clinical findings alone. Adaptive-optics imaging previously demonstrated a sparse mosaic of normal wave-guiding cones remaining at the fovea, with no visible structure outside the central fovea in oligocone trichromacy. In contrast, the subjects presented in this study with molecularly confirmed bradyopsia had a relatively intact and structurally normal photoreceptor mosaic, allowing the distinction between these disorders based on the cellular phenotype and suggesting different pathomechanisms. äRetinal Architecture in ?RGS9- and ?R9AP-Associated Retinal Dysfunctio(epmc).pdf DeepDyve Pubget Overpricing