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10.1038/ni.3290 http://scihub22266oqcxt.onion/10.1038/ni.3290 C4653079!4653079!26502405     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2015 ; 16 (12): 1235-44 Nephropedia Template TP {{tp|p=26502405|t=2015. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma |pdf=|usr=}}{{26502405}} gab.com Text Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26502405 #FOAvip Ectopic lymphoid-like structures (ELS) are often observed in cancer, yet their function is obscure. Although ELSs signify good prognosis in certain malignancies, we found that hepatic ELSs indicate poor prognosis in hepatocellular carcinoma (HCC). We studied an HCC mouse model, displaying abundant ELSs and found that they constitute immunopathological microniches, wherein progenitor malignant hepatocytes appear and thrive in a complex cellular and cytokine milieu until gaining self-sufficiency. Progenitor egression and tumor formation is associated with autocrine production of cytokines previously provided by the niche. ELSs develop upon cooperation between the innate and adaptive immune system which is facilitated by NF-?B activation and abolished by T cell depletion. These aberrant immune foci could be new targets for cancer therapy. Twit Text FOAVip Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26502405 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26502405 #FOAvip English Wikipedia <ref>{{Cite pmid|26502405}}</ref> Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma #MMPMID26502405 Finkin S; Yuan D; Stein I; Taniguchi K; Weber A; Unger K; Browning JL; Goossens N; Nakagawa S; Gunasekaran G; Schwartz ME; Kobayashi M; Kumada H; Berger M; Pappo O; Rajewsky K; Hoshida Y; Karin M; Heikenwalder M; Ben-Neriah Y; Pikarsky E Nat Immunol 2015[Dec]; 16 (12): 1235-44 PMID26502405show ga Ectopic lymphoid-like structures (ELS) are often observed in cancer, yet their function is obscure. Although ELSs signify good prognosis in certain malignancies, we found that hepatic ELSs indicate poor prognosis in hepatocellular carcinoma (HCC). We studied an HCC mouse model, displaying abundant ELSs and found that they constitute immunopathological microniches, wherein progenitor malignant hepatocytes appear and thrive in a complex cellular and cytokine milieu until gaining self-sufficiency. Progenitor egression and tumor formation is associated with autocrine production of cytokines previously provided by the niche. ELSs develop upon cooperation between the innate and adaptive immune system which is facilitated by NF-?B activation and abolished by T cell depletion. These aberrant immune foci could be new targets for cancer therapy. äEctopic lymphoid structures function as microniches for tumor progenit(epmc).pdf DeepDyve Pubget Overpricing