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10.1038/ni.3290 http://scihub22266oqcxt.onion/10.1038/ni.3290 C4653079!4653079 !26502405     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26502405 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Immunol 2015 ; 16 (12 ): 1235-44 Nephropedia Template TP {{tp|p=26502405 |t=2015. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma |pdf=|usr=}}{{26502405 }} gab.com Text Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26502405 #FOAvip Ectopic lymphoid-like structures (ELSs) are often observed in cancer, yet their function is obscure. Although ELSs signify good prognosis in certain malignancies, we found that hepatic ELSs indicated poor prognosis for hepatocellular carcinoma (HCC). We studied an HCC mouse model that displayed abundant ELSs and found that they constituted immunopathological microniches wherein malignant hepatocyte progenitor cells appeared and thrived in a complex cellular and cytokine milieu until gaining self-sufficiency. The egress of progenitor cells and tumor formation were associated with the autocrine production of cytokines previously provided by the niche. ELSs developed via cooperation between the innate immune system and adaptive immune system, an event facilitated by activation of the transcription factor NF-?B and abolished by depletion of T cells. Such aberrant immunological foci might represent new targets for cancer therapy. Twit Text FOAVip Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26502405 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26502405 #FOAvip English Wikipedia <ref>{{Cite pmid|26502405 }}</ref> Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma #MMPMID26502405 Finkin S ; Yuan D ; Stein I ; Taniguchi K ; Weber A ; Unger K ; Browning JL ; Goossens N ; Nakagawa S ; Gunasekaran G ; Schwartz ME ; Kobayashi M ; Kumada H ; Berger M ; Pappo O ; Rajewsky K ; Hoshida Y ; Karin M ; Heikenwalder M ; Ben-Neriah Y ; Pikarsky E Nat Immunol 2015[Dec]; 16 (12 ): 1235-44 PMID26502405 show ga Ectopic lymphoid-like structures (ELSs) are often observed in cancer, yet their function is obscure. Although ELSs signify good prognosis in certain malignancies, we found that hepatic ELSs indicated poor prognosis for hepatocellular carcinoma (HCC). We studied an HCC mouse model that displayed abundant ELSs and found that they constituted immunopathological microniches wherein malignant hepatocyte progenitor cells appeared and thrived in a complex cellular and cytokine milieu until gaining self-sufficiency. The egress of progenitor cells and tumor formation were associated with the autocrine production of cytokines previously provided by the niche. ELSs developed via cooperation between the innate immune system and adaptive immune system, an event facilitated by activation of the transcription factor NF-?B and abolished by depletion of T cells. Such aberrant immunological foci might represent new targets for cancer therapy. |Adaptive Immunity/genetics/immunology [MESH] |Animals [MESH] |Carcinoma, Hepatocellular/genetics/*immunology/metabolism [MESH] |Comparative Genomic Hybridization [MESH] |Cytokines/genetics/immunology/metabolism [MESH] |Disease Models, Animal [MESH] |Hepatocytes/immunology/metabolism/pathology [MESH] |Humans [MESH] |I-kappa B Kinase/genetics/immunology/metabolism [MESH] |Immunity, Innate/genetics/immunology [MESH] |Immunoblotting [MESH] |In Situ Hybridization [MESH] |Liver Neoplasms/genetics/*immunology/metabolism [MESH] |Lymphoid Tissue/*immunology/metabolism/pathology [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |NF-kappa B/genetics/immunology/metabolism [MESH] |Neoplastic Stem Cells/*immunology/metabolism [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Stem Cell Niche/genetics/*immunology [MESH] |T-Lymphocytes/immunology/metabolism [MESH]Ectopic lymphoid structures function as microniches for tumor progenit(epmc).pdf DeepDyve Pubget Overpricing