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2015 ; 6
(24
): 20540-54
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Dragon (repulsive guidance molecule b, RGMb) is a novel gene that promotes
colorectal cancer growth
#MMPMID26029998
Shi Y
; Chen GB
; Huang XX
; Xiao CX
; Wang HH
; Li YS
; Zhang JF
; Li S
; Xia Y
; Ren JL
; Guleng B
Oncotarget
2015[Aug]; 6
(24
): 20540-54
PMID26029998
show ga
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and a major
cause of cancer death. However, the molecular mechanisms underlying CRC
initiation, growth and metastasis are poorly understood. Dragon (RGMb), a member
of the repulsive guidance molecule (RGM) family, has been recently identified as
a co-receptor for bone morphogenetic protein (BMP) signaling, but the role of
Dragon in CRC development is undefined. Here, we show that Dragon expression was
increased in colon cancer tissues compared to control tissues in CAC mouse model
and in human patients. Dragon promoted proliferation of CT26.WT and CMT93 colon
cancer cells and accelerated tumor growth in the xenograft mouse model. Dragon's
action on colon cancer development was mediated via the BMP4-Smad1/5/8 and Erk1/2
pathways. Therefore, our results have revealed that Dragon is a novel gene that
promotes CRC growth through the BMP pathway. Dragon may be exploited as a
potential therapeutic target for CRC treatment.