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10.18632/oncotarget.4110

http://scihub22266oqcxt.onion/10.18632/oncotarget.4110
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suck abstract from ncbi


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pmid26029998
      Oncotarget 2015 ; 6 (24 ): 20540-54
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  • Dragon (repulsive guidance molecule b, RGMb) is a novel gene that promotes colorectal cancer growth #MMPMID26029998
  • Shi Y ; Chen GB ; Huang XX ; Xiao CX ; Wang HH ; Li YS ; Zhang JF ; Li S ; Xia Y ; Ren JL ; Guleng B
  • Oncotarget 2015[Aug]; 6 (24 ): 20540-54 PMID26029998 show ga
  • Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and a major cause of cancer death. However, the molecular mechanisms underlying CRC initiation, growth and metastasis are poorly understood. Dragon (RGMb), a member of the repulsive guidance molecule (RGM) family, has been recently identified as a co-receptor for bone morphogenetic protein (BMP) signaling, but the role of Dragon in CRC development is undefined. Here, we show that Dragon expression was increased in colon cancer tissues compared to control tissues in CAC mouse model and in human patients. Dragon promoted proliferation of CT26.WT and CMT93 colon cancer cells and accelerated tumor growth in the xenograft mouse model. Dragon's action on colon cancer development was mediated via the BMP4-Smad1/5/8 and Erk1/2 pathways. Therefore, our results have revealed that Dragon is a novel gene that promotes CRC growth through the BMP pathway. Dragon may be exploited as a potential therapeutic target for CRC treatment.
  • |Animals [MESH]
  • |Cell Adhesion Molecules, Neuronal/biosynthesis/*genetics [MESH]
  • |Cell Proliferation/genetics [MESH]
  • |Colorectal Neoplasms/*genetics/metabolism/*pathology [MESH]
  • |GPI-Linked Proteins [MESH]
  • |Gene Knockdown Techniques [MESH]
  • |Humans [MESH]
  • |Mice [MESH]
  • |Mice, Inbred BALB C [MESH]
  • |Mice, Inbred C57BL [MESH]
  • |Nerve Tissue Proteins/biosynthesis/*genetics [MESH]
  • |Signal Transduction [MESH]


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