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10.18632/oncotarget.3896 http://scihub22266oqcxt.onion/10.18632/oncotarget.3896 C4652996!4652996 !26036631     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26036631 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2015 ; 6 (24 ): 20177-89 Nephropedia Template TP {{tp|p=26036631 |t=2015. The 14-3-3?/GSK3?/?-catenin/ZEB1 regulatory loop modulates chemo-sensitivity in human tongue cancer |pdf=|usr=}}{{26036631 }} gab.com Text The 14-3-3 /GSK3 / -catenin/ZEB1 regulatory loop modulates chemo-sensitivity in human tongue cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26036631 #FOAvip Here we demonstrated that chemotherapy induced 14-3-3? expression in tongue cancer (TC) cells and overexpressed 14-3-3? sensitized TC cells to chemotherapy especially in multidrug resistant TC (MDR-TC) cells. In agreement, 14-3-3? knockdown enhanced resistance of TC cells to chemotherapy. Mechanically, we found 14-3-3? physically bound to GSK3? in protein level and the binding inhibited ?-catenin signaling. Coincidentally, chemotherapy as well as 14-3-3? overexpression led to increase of GSK3? protein level. Increased GSK3? protein sensitized TC cells to chemotherapy. Moreover, deregulation of 14-3-3?/GSK3?/?-catenin axis led to overexpressed ZEB1 in TC cells, especially in MDR-TC cells. As a negative feedback loop, ZEB1 bond to 14-3-3? promoter to enhance promoter hypermethylation in TC cells. Promoter hypermethylation resulted into the decrease of 14-3-3? expression. Importantly, a positive correlation was observed between 14-3-3? and GSK3? protein expression in TC tissues from patients receiving chemotherapy. High levels of 14-3-3? and GSK3? were associated with better prognosis in TC patients. Twit Text FOAVip The 14-3-3 /GSK3 / -catenin/ZEB1 regulatory loop modulates chemo-sensitivity in human tongue cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26036631 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26036631 #FOAvip English Wikipedia <ref>{{Cite pmid|26036631 }}</ref> The 14-3-3?/GSK3?/?-catenin/ZEB1 regulatory loop modulates chemo-sensitivity in human tongue cancer #MMPMID26036631 Peng C ; Jia X ; Xiong Y ; Yin J ; Li N ; Deng Y ; Luo K ; Zhang Q ; Wang C ; Zhang Z ; Zheng G ; He Z Oncotarget 2015[Aug]; 6 (24 ): 20177-89 PMID26036631 show ga Here we demonstrated that chemotherapy induced 14-3-3? expression in tongue cancer (TC) cells and overexpressed 14-3-3? sensitized TC cells to chemotherapy especially in multidrug resistant TC (MDR-TC) cells. In agreement, 14-3-3? knockdown enhanced resistance of TC cells to chemotherapy. Mechanically, we found 14-3-3? physically bound to GSK3? in protein level and the binding inhibited ?-catenin signaling. Coincidentally, chemotherapy as well as 14-3-3? overexpression led to increase of GSK3? protein level. Increased GSK3? protein sensitized TC cells to chemotherapy. Moreover, deregulation of 14-3-3?/GSK3?/?-catenin axis led to overexpressed ZEB1 in TC cells, especially in MDR-TC cells. As a negative feedback loop, ZEB1 bond to 14-3-3? promoter to enhance promoter hypermethylation in TC cells. Promoter hypermethylation resulted into the decrease of 14-3-3? expression. Importantly, a positive correlation was observed between 14-3-3? and GSK3? protein expression in TC tissues from patients receiving chemotherapy. High levels of 14-3-3? and GSK3? were associated with better prognosis in TC patients. |14-3-3 Proteins/*genetics/*metabolism [MESH] |Carcinoma, Squamous Cell/*genetics [MESH] |Catenins/*genetics/*metabolism [MESH] |Glycogen Synthase Kinase 3 beta [MESH] |Glycogen Synthase Kinase 3/*genetics/*metabolism [MESH] |Homeodomain Proteins/*genetics/*metabolism [MESH] |Humans [MESH] |Signal Transduction [MESH] |Tongue Neoplasms/*genetics [MESH] |Transcription Factors/*genetics/*metabolism [MESH] |Transfection [MESH]The 14-3-3?/GSK3?/?-catenin/ZEB1 regulatory loop modulates chemo-sensi(epmc).pdf DeepDyve Pubget Overpricing