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10.1042/BJ20150404

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C4652938!4652938!26348909
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suck abstract from ncbi


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pmid26348909      Biochem+J 2015 ; 470 (Pt 2): 207-21
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  • GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling #MMPMID26348909
  • Stretton C; Hoffmann T; Munson MJ; Prescott A; Taylor P; Ganley I; Hundal H
  • Biochem J 2015[Sep]; 470 (Pt 2): 207-21 PMID26348909show ga
  • Glycogen synthase kinase-3 (GSK3) mediates phosphorylation of raptor on Ser859, which crucially supports activation of mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) signalling in response to amino acid availability. GSK3 inhibition is associated with reduced mTORC1 signalling that impacts negatively on cell growth, protein synthesis and promotes cellular autophagy.
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