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10.1093/nar/gkv810 http://scihub22266oqcxt.onion/10.1093/nar/gkv810 C4652780!4652780 !26261215     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26261215 &cmd=llinks): Failed to open stream: HTTP request failed! 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Integrated analysis of numerous heterogeneous gene expression profiles for detecting robust disease-specific biomarkers and proposing drug targets |pdf=|usr=}}{{26261215 }} gab.com Text Integrated analysis of numerous heterogeneous gene expression profiles for detecting robust disease-specific biomarkers and proposing drug targets JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26261215 #FOAvip Genome-wide expression profiling has revolutionized biomedical research; vast amounts of expression data from numerous studies of many diseases are now available. Making the best use of this resource in order to better understand disease processes and treatment remains an open challenge. In particular, disease biomarkers detected in case-control studies suffer from low reliability and are only weakly reproducible. Here, we present a systematic integrative analysis methodology to overcome these shortcomings. We assembled and manually curated more than 14,000 expression profiles spanning 48 diseases and 18 expression platforms. We show that when studying a particular disease, judicious utilization of profiles from other diseases and information on disease hierarchy improves classification quality, avoids overoptimistic evaluation of that quality, and enhances disease-specific biomarker discovery. This approach yielded specific biomarkers for 24 of the analyzed diseases. We demonstrate how to combine these biomarkers with large-scale interaction, mutation and drug target data, forming a highly valuable disease summary that suggests novel directions in disease understanding and drug repurposing. Our analysis also estimates the number of samples required to reach a desired level of biomarker stability. This methodology can greatly improve the exploitation of the mountain of expression profiles for better disease analysis. Twit Text FOAVip Integrated analysis of numerous heterogeneous gene expression profiles for detecting robust disease-specific biomarkers and proposing drug targets ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26261215 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26261215 #FOAvip English Wikipedia <ref>{{Cite pmid|26261215 }}</ref> Integrated analysis of numerous heterogeneous gene expression profiles for detecting robust disease-specific biomarkers and proposing drug targets #MMPMID26261215 Amar D ; Hait T ; Izraeli S ; Shamir R Nucleic Acids Res 2015[Sep]; 43 (16 ): 7779-89 PMID26261215 show ga Genome-wide expression profiling has revolutionized biomedical research; vast amounts of expression data from numerous studies of many diseases are now available. Making the best use of this resource in order to better understand disease processes and treatment remains an open challenge. In particular, disease biomarkers detected in case-control studies suffer from low reliability and are only weakly reproducible. Here, we present a systematic integrative analysis methodology to overcome these shortcomings. We assembled and manually curated more than 14,000 expression profiles spanning 48 diseases and 18 expression platforms. We show that when studying a particular disease, judicious utilization of profiles from other diseases and information on disease hierarchy improves classification quality, avoids overoptimistic evaluation of that quality, and enhances disease-specific biomarker discovery. This approach yielded specific biomarkers for 24 of the analyzed diseases. We demonstrate how to combine these biomarkers with large-scale interaction, mutation and drug target data, forming a highly valuable disease summary that suggests novel directions in disease understanding and drug repurposing. Our analysis also estimates the number of samples required to reach a desired level of biomarker stability. This methodology can greatly improve the exploitation of the mountain of expression profiles for better disease analysis. |Algorithms [MESH] |Antineoplastic Agents/therapeutic use [MESH] |Biomarkers/*analysis/metabolism [MESH] |Disease/*genetics [MESH] |Gene Expression Profiling/*methods [MESH] |Genetic Variation [MESH] |Humans [MESH] |Neoplasms/drug therapy/genetics/metabolism [MESH] |Polymorphism, Single Nucleotide [MESH]Integrated analysis of numerous heterogeneous gene expression profiles(epmc).pdf DeepDyve Pubget Overpricing