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2015 ; 10
(4
): 284-8
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The use of Quantiferon-TB gold in-tube test in screening latent tuberculosis
among Saudi Arabia dialysis patients
#MMPMID26664568
Al Wakeel JS
; Makoshi Z
; Al Ghonaim M
; Al Harbi A
; Al Suwaida A
; Algahtani F
; Al Hedaithy M
; Almogairin S
; Abdullah S
Ann Thorac Med
2015[Oct]; 10
(4
): 284-8
PMID26664568
show ga
BACKGROUND AND AIM: Screening for tuberculosis (TB) is a key strategy for
controlling infection. This study aimed to detect latent TB among dialysis
patients. METHODS: This is a prospective study conducted in King Saud University,
Riyadh involving hemodialysis (HD) and peritoneal dialysis (PD) patients aged ?18
years. Patients were screened for latent TB infection (LTBI) using both TBskin
test (TST) and QuantiFERONTB Gold In-Tube test (QFT-GIT). All participants were
followed-up clinically and radiologically every 3 months for 2 years. RESULTS: A
total of 243 (181 HD and 62 PD) patients were included and 112(46.1%) were males.
45.3% showed positive QFT in HD patients with sensitivity of 91.7%, specificity
of 71.4%, positive predictive value (PPV) of 19.5%, and negative predictive value
(NPV) of 91.1%. TST results in HD showed that positive TST was 17.4%, sensitivity
was 63.2%, specificity was 95.5%, PPV was 51.5%, and NPV was 91.1%. Five (8.1%)
showed positive QFT in PD patients with sensitivity of 7.7%, specificity of
91.8%, PPV of 6.6%, and NPV of 92.3%. TST results in PD showed that positive TST
was 9.8%, sensitivity was 35.7%, specificity was 97.9%, PPV was 55.8%, and NPV
was 93.3%. Previous TB infection was significantly correlated with QFT only in HD
patients, but significantly associated with TST in both HD and PD patients. Also
in HD, QFT was significantly associated with TST (P = 0.043). CONCLUSIONS: Due to
high variability of QFT-GIT sensitivity, we recommend its use for its NPV and to
use either TST or QFT in screening latent TB.
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