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10.1177/2058460115609635

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suck abstract from ncbi


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pmid26634147
      Acta+Radiol+Open 2015 ; 4 (11 ): 2058460115609635
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  • MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain #MMPMID26634147
  • Eide PK ; Ringstad G
  • Acta Radiol Open 2015[Nov]; 4 (11 ): 2058460115609635 PMID26634147 show ga
  • Recently, the "glymphatic system" of the brain has been discovered in rodents, which is a paravascular, transparenchymal route for clearance of excess brain metabolites and distribution of compounds in the cerebrospinal fluid. It has already been demonstrated that intrathecally administered gadolinium (Gd) contrast medium distributes along this route in rats, but so far not in humans. A 27-year-old woman underwent magnetic resonance imaging (MRI) with intrathecal administration of gadobutrol, which distributed throughout her entire brain after 1 and 4.5?h. MRI with intrathecal Gd may become a tool to study glymphatic function in the human brain.
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