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10.1038/nn.3906 http://scihub22266oqcxt.onion/10.1038/nn.3906 C4651918!4651918!25531572     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Neurosci 2015 ; 18 (2): 210-8 Nephropedia Template TP {{tp|p=25531572|t=2015. Calcium dynamics in astrocyte processes during neurovascular coupling |pdf=|usr=}}{{25531572}} gab.com Text Calcium dynamics in astrocyte processes during neurovascular coupling JO: Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25531572 #FOAvip Enhanced neuronal activity in the brain triggers a local increase in blood flow, termed functional hyperemia, via several mechanisms, including calcium (Ca2+) signaling in astrocytes. However, recent in vivo studies have questioned the role of astrocytes in functional hyperemia because of the slow and sparse dynamics of their somatic Ca2+ signals and the absence of glutamate metabotropic receptor 5 in adults. Here, we reexamined their role in neurovascular coupling by selectively expressing a genetically encoded Ca2+ sensor in astrocytes of the olfactory bulb. We show that in anesthetized mice, the physiological activation of olfactory sensory neuron (OSN) terminals reliably triggers Ca2+ increases in astrocyte processes but not in somata. These Ca2+ increases systematically precede the onset of functional hyperemia by 1?2 s, reestablishing astrocytes as potential regulators of neurovascular coupling. Twit Text FOAVip Calcium dynamics in astrocyte processes during neurovascular coupling ????Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25531572 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25531572 #FOAvip English Wikipedia <ref>{{Cite pmid|25531572}}</ref> Calcium dynamics in astrocyte processes during neurovascular coupling #MMPMID25531572 Otsu Y; Couchman K; Lyons DG; Collot M; Agarwal A; Mallet JM; Pfrieger FW; Bergles DE; Charpak S Nat Neurosci 2015[Feb]; 18 (2): 210-8 PMID25531572show ga Enhanced neuronal activity in the brain triggers a local increase in blood flow, termed functional hyperemia, via several mechanisms, including calcium (Ca2+) signaling in astrocytes. However, recent in vivo studies have questioned the role of astrocytes in functional hyperemia because of the slow and sparse dynamics of their somatic Ca2+ signals and the absence of glutamate metabotropic receptor 5 in adults. Here, we reexamined their role in neurovascular coupling by selectively expressing a genetically encoded Ca2+ sensor in astrocytes of the olfactory bulb. We show that in anesthetized mice, the physiological activation of olfactory sensory neuron (OSN) terminals reliably triggers Ca2+ increases in astrocyte processes but not in somata. These Ca2+ increases systematically precede the onset of functional hyperemia by 1?2 s, reestablishing astrocytes as potential regulators of neurovascular coupling. äCalcium dynamics in astrocyte processes during neurovascular coupling (epmc).pdf DeepDyve Pubget Overpricing