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10.1158/0008-5472.CAN-15-0896 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-15-0896 C4651828!4651828!26404002     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2015 ; 75 (22): 4852-62 Nephropedia Template TP {{tp|p=26404002|t=2015. IL-17 functions through the novel REG3?-JAK2-STAT3 inflammatory pathway to promote the transition from chronic pancreatitis to pancreatic cancer |pdf=|usr=}}{{26404002}} gab.com Text IL-17 functions through the novel REG3 -JAK2-STAT3 inflammatory pathway to promote the transition from chronic pancreatitis to pancreatic cancer JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26404002 #FOAvip Pancreatic ductal adenocarcinoma (PDAC) offers an optimal model for discovering ?druggable? molecular pathways that participate in inflammation-associated cancer development. Chronic pancreatitis, a common prolonged inflammatory disease, behaves as a well-known premalignant condition that contributes to PDAC development. Although the mechanisms underlying the pancreatitis-to-cancer transition remain to be fully elucidated, emerging evidence supports the hypothesis that the actions of proinflammatory mediators on cells harboring Kras mutations promote neoplastic transformation. Recent elegant studies demonstrated that the IL-17 pathway mediates this phenomenon and can be targeted with antibodies, but the downstream mechanisms by which IL-17 functions during this transition are currently unclear. In this study, we demonstrate that IL-17 induces the expression of REG3?, a well-known mediator of pancreatitis, during acinar-to-ductal metaplasia and in early PanIN lesions. Furthermore, we found that REG3? promotes cell growth and decreases sensitivity to cell death through activation of the gp130-JAK2-STAT3-dependent pathway. Genetic inactivation of REG3? in the context of oncogenic Kras-driven PDAC resulted in reduced PanIN formation, an effect that could be rescued by administration of exogenous REG3?. Taken together, our findings provide mechanistic insight into the pathways underlying inflammation-associated pancreatic cancer, revealing a dual and contextual pathophysiological role for REG3? during pancreatitis and PDAC initiation. Twit Text FOAVip IL-17 functions through the novel REG3 -JAK2-STAT3 inflammatory pathway to promote the transition from chronic pancreatitis to pancreatic cancer ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26404002 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26404002 #FOAvip English Wikipedia <ref>{{Cite pmid|26404002}}</ref> IL-17 functions through the novel REG3?-JAK2-STAT3 inflammatory pathway to promote the transition from chronic pancreatitis to pancreatic cancer #MMPMID26404002 Loncle C; Bonjoch L; Folch-Puy E; Lopez-Millan MB; Lac S; Molejon MI; Chuluyan E; Cordelier P; Dubus P; Lomberk G; Urrutia R; Closa D; Iovanna JL Cancer Res 2015[Nov]; 75 (22): 4852-62 PMID26404002show ga Pancreatic ductal adenocarcinoma (PDAC) offers an optimal model for discovering ?druggable? molecular pathways that participate in inflammation-associated cancer development. Chronic pancreatitis, a common prolonged inflammatory disease, behaves as a well-known premalignant condition that contributes to PDAC development. Although the mechanisms underlying the pancreatitis-to-cancer transition remain to be fully elucidated, emerging evidence supports the hypothesis that the actions of proinflammatory mediators on cells harboring Kras mutations promote neoplastic transformation. Recent elegant studies demonstrated that the IL-17 pathway mediates this phenomenon and can be targeted with antibodies, but the downstream mechanisms by which IL-17 functions during this transition are currently unclear. In this study, we demonstrate that IL-17 induces the expression of REG3?, a well-known mediator of pancreatitis, during acinar-to-ductal metaplasia and in early PanIN lesions. Furthermore, we found that REG3? promotes cell growth and decreases sensitivity to cell death through activation of the gp130-JAK2-STAT3-dependent pathway. Genetic inactivation of REG3? in the context of oncogenic Kras-driven PDAC resulted in reduced PanIN formation, an effect that could be rescued by administration of exogenous REG3?. Taken together, our findings provide mechanistic insight into the pathways underlying inflammation-associated pancreatic cancer, revealing a dual and contextual pathophysiological role for REG3? during pancreatitis and PDAC initiation. äIL-17 functions through the novel REG3?-JAK2-STAT3 inflammatory pathwa(epmc).pdf DeepDyve Pubget Overpricing