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10.1158/0008-5472.CAN-14-2345 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-14-2345 C4651709!4651709!26383165     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2015 ; 75 (22): 4863-75 Nephropedia Template TP {{tp|p=26383165|t=2015. Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer |pdf=|usr=}}{{26383165}} gab.com Text Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26383165 #FOAvip Preventing breast cancer will require the development of targeted strategies that can effectively block disease progression. Tamoxifen and aromatase inhibitors are effective in addressing estrogen receptor-positive (ER+) breast cancer development, but estrogen receptor-negative (ER?) breast cancer remains an unmet challenge due to gaps in pathobiological understanding. In this study, we used reverse phase protein array (RPPA) to identify activation of Src kinase as an early signaling alteration in premalignant breast lesions of women who did not respond to tamoxifen, a widely used ER antagonist for hormonal therapy of breast cancer. Src kinase blockade with the small molecule inhibitor saracatinib prevented the disorganized 3D growth of ER? mammary epithelial cells in vitro and delayed the development of pre-malignant lesions and tumors in vivo in mouse models developing HER2+ and ER? mammary tumors, extending tumor-free and overall survival. Mechanistic investigations revealed that Src blockade reduced glucose metabolism as a result of an inhibition in ERK1/2-MNK1-eIF4E-mediated cap-dependent translation of c-Myc and transcription of the glucose transporter GLUT1, thereby limiting energy available for cell growth. Taken together, our results provide a sound rationale to target Src pathways in premalignant breast lesions to limit the development of breast cancers. Twit Text FOAVip Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26383165 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26383165 #FOAvip English Wikipedia <ref>{{Cite pmid|26383165}}</ref> Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer #MMPMID26383165 Jain S; Wang X; Chang CC; Ibarra-Drendall C; Wang H; Zhang Q; Brady SW; Li P; Zhao H; Dobbs J; Kyrish M; Tkaczyk TS; Ambrose A; Sistrunk C; Arun B; Richards-Kortum R; Jia W; Seewaldt VL; Yu D Cancer Res 2015[Nov]; 75 (22): 4863-75 PMID26383165show ga Preventing breast cancer will require the development of targeted strategies that can effectively block disease progression. Tamoxifen and aromatase inhibitors are effective in addressing estrogen receptor-positive (ER+) breast cancer development, but estrogen receptor-negative (ER?) breast cancer remains an unmet challenge due to gaps in pathobiological understanding. In this study, we used reverse phase protein array (RPPA) to identify activation of Src kinase as an early signaling alteration in premalignant breast lesions of women who did not respond to tamoxifen, a widely used ER antagonist for hormonal therapy of breast cancer. Src kinase blockade with the small molecule inhibitor saracatinib prevented the disorganized 3D growth of ER? mammary epithelial cells in vitro and delayed the development of pre-malignant lesions and tumors in vivo in mouse models developing HER2+ and ER? mammary tumors, extending tumor-free and overall survival. Mechanistic investigations revealed that Src blockade reduced glucose metabolism as a result of an inhibition in ERK1/2-MNK1-eIF4E-mediated cap-dependent translation of c-Myc and transcription of the glucose transporter GLUT1, thereby limiting energy available for cell growth. Taken together, our results provide a sound rationale to target Src pathways in premalignant breast lesions to limit the development of breast cancers. äSrc Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prev(epmc).pdf DeepDyve Pubget Overpricing