Regional Hippocampal Damage in Heart Failure #MMPMID25704495
Woo MA; Ogren JA; Abouzeid CM; Macey PM; Sairafian KG; Saharan PS; Thompson PM; Fonarow GC; Hamilton MA; Harper RM; Kumar R
Eur J Heart Fail 2015[May]; 17 (5): 494-500 PMID25704495show ga
Aims: Heart failure (HF) patients show cognitive and mood impairments, including short-term memory loss and depression, adversely impacting quality of life and self-care management. Brain regions, including the hippocampus, a structure significantly involved in memory and mood, show injury in HF, but the integrity of specific hippocampal subregions is unclear. Methods and results: To assess regional hippocampal volume loss, we evaluated 17 HF patients (mean age ± SD, 54.4 ± 2.0 years; 12 male, LVEF 28.3 ± 6.8%; NYHA Class II/III 94%/6%) and 34 healthy control subjects (52.3 ± 1.3 years; 24 male) using high-resolution T1-weighted magnetic resonance imaging and evaluated localized surface changes with morphometric procedures. Hippocampi were manually outlined, and volumes calculated from normalized tracings.Volume differences between groups were assessed by two-sample t-tests, and regional differences were assessed by surface morphometry. HF patients exhibited smaller hippocampal volumes than controls (Right: 3060±146 vs. 3478±94 mm3; p = 0.02, Left: 3021±145 vs. 3352±98 mm3; p = 0.06). Volume reductions were detected principally in CA1, an area integral to an array of learning and memory functions, as well as in mid- to posterior CA3 and subiculum. Conclusion: The hippocampus shows regional volume reduction in HF, which may contribute to short-term memory loss and depression associated with the condition.
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Eur+J+Heart+Fail 2015 ; 17 (5): 494-500
