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2015 ; 32
(11
): 2919-31
Nephropedia Template TP
gab.com Text
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English Wikipedia
How Do Genomes Create Novel Phenotypes? Insights from the Loss of the Worker
Caste in Ant Social Parasites
#MMPMID26226984
Smith CR
; Helms Cahan S
; Kemena C
; Brady SG
; Yang W
; Bornberg-Bauer E
; Eriksson T
; Gadau J
; Helmkampf M
; Gotzek D
; Okamoto Miyakawa M
; Suarez AV
; Mikheyev A
Mol Biol Evol
2015[Nov]; 32
(11
): 2919-31
PMID26226984
show ga
A central goal of biology is to uncover the genetic basis for the origin of new
phenotypes. A particularly effective approach is to examine the genomic
architecture of species that have secondarily lost a phenotype with respect to
their close relatives. In the eusocial Hymenoptera, queens and workers have
divergent phenotypes that may be produced via either expression of alternative
sets of caste-specific genes and pathways or differences in expression patterns
of a shared set of multifunctional genes. To distinguish between these two
hypotheses, we investigated how secondary loss of the worker phenotype in
workerless ant social parasites impacted genome evolution across two independent
origins of social parasitism in the ant genera Pogonomyrmex and Vollenhovia. We
sequenced the genomes of three social parasites and their most-closely related
eusocial host species and compared gene losses in social parasites with gene
expression differences between host queens and workers. Virtually all annotated
genes were expressed to some degree in both castes of the host, with most
shifting in queen-worker bias across developmental stages. As a result, despite
>1 My of divergence from the last common ancestor that had workers, the social
parasites showed strikingly little evidence of gene loss, damaging mutations, or
shifts in selection regime resulting from loss of the worker caste. This suggests
that regulatory changes within a multifunctional genome, rather than sequence
differences, have played a predominant role in the evolution of social
parasitism, and perhaps also in the many gains and losses of phenotypes in the
social insects.