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10.1016/j.celrep.2015.02.054 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.02.054 C4651178!4651178 !25801033     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25801033 &cmd=llinks): Failed to open stream: HTTP request failed! 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Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet ? cells |pdf=|usr=}}{{25801033 }} gab.com Text Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet cells JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25801033 #FOAvip Pdx1 is a transcription factor of fundamental importance to pancreas formation and adult islet ? cell function. However, little is known about the positive- and negative-acting coregulators recruited to mediate transcriptional control. Here, we isolated numerous Pdx1-interacting factors possessing a wide range of cellular functions linked with this protein, including, but not limited to, coregulators associated with transcriptional activation and repression, DNA damage response, and DNA replication. Because chromatin remodeling activities are essential to developmental lineage decisions and adult cell function, our analysis focused on investigating the influence of the Swi/Snf chromatin remodeler on Pdx1 action. The two mutually exclusive and indispensable Swi/Snf core ATPase subunits, Brg1 and Brm, distinctly affected target gene expression in ? cells. Furthermore, physiological and pathophysiological conditions dynamically regulated Pdx1 binding to these Swi/Snf complexes in vivo. We discuss how context-dependent recruitment of coregulatory complexes by Pdx1 could impact pancreas cell development and adult islet ? cell activity. Twit Text FOAVip Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet cells ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25801033 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25801033 #FOAvip English Wikipedia <ref>{{Cite pmid|25801033 }}</ref> Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet ? cells #MMPMID25801033 McKenna B ; Guo M ; Reynolds A ; Hara M ; Stein R Cell Rep 2015[Mar]; 10 (12 ): 2032-42 PMID25801033 show ga Pdx1 is a transcription factor of fundamental importance to pancreas formation and adult islet ? cell function. However, little is known about the positive- and negative-acting coregulators recruited to mediate transcriptional control. Here, we isolated numerous Pdx1-interacting factors possessing a wide range of cellular functions linked with this protein, including, but not limited to, coregulators associated with transcriptional activation and repression, DNA damage response, and DNA replication. Because chromatin remodeling activities are essential to developmental lineage decisions and adult cell function, our analysis focused on investigating the influence of the Swi/Snf chromatin remodeler on Pdx1 action. The two mutually exclusive and indispensable Swi/Snf core ATPase subunits, Brg1 and Brm, distinctly affected target gene expression in ? cells. Furthermore, physiological and pathophysiological conditions dynamically regulated Pdx1 binding to these Swi/Snf complexes in vivo. We discuss how context-dependent recruitment of coregulatory complexes by Pdx1 could impact pancreas cell development and adult islet ? cell activity. |Animals [MESH] |Cell Differentiation/*genetics [MESH] |Cell Line, Tumor [MESH] |Cell Nucleus/metabolism [MESH] |Chromatin Assembly and Disassembly/*genetics [MESH] |Chromatin/genetics [MESH] |Chromosomal Proteins, Non-Histone/*metabolism [MESH] |Gene Expression Regulation/*physiology [MESH] |Homeodomain Proteins/*metabolism [MESH] |Humans [MESH] |Insulin-Secreting Cells/*metabolism [MESH] |Mice [MESH] |Trans-Activators/*metabolism [MESH]Dynamic recruitment of functionally distinct Swi/Snf chromatin remodel(epmc).pdf DeepDyve Pubget Overpricing