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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Clin+Infect+Dis 2014 ; 59 (11): 1588-92 Nephropedia Template TP
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Treating Progressive Multifocal Leukoencephalopathy With Interleukin 7 and Vaccination With JC Virus Capsid Protein VP1 #MMPMID25214510
Sospedra M; Schippling S; Yousef S; Jelcic I; Bofill-Mas S; Planas R; Stellmann JP; Demina V; Cinque P; Garcea R; Croughs T; Girones R; Martin R
Clin Infect Dis 2014[Dec]; 59 (11): 1588-92 PMID25214510show ga
Progressive multifocal leukoencephalopathy is a currently untreatable infection of the brain. Here, we demonstrate in 2 patients that treatment with interleukin 7, JC polyomavirus (JCV) capsid protein VP1, and a Toll-like receptor 7 agonist used as adjuvant, was well tolerated, and showed a very favorable safety profile and unexpected efficacy that warrant further investigation.