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10.1038/cddis.2015.167 http://scihub22266oqcxt.onion/10.1038/cddis.2015.167 C4650720!4650720!26203860     free     free     free       Cell+Death+Dis 2015 ; 6 (7): e1831- Nephropedia Template TP {{tp|p=26203860|t=2015. Genome-editing tools for stem cell biology |pdf=|usr=}}{{26203860}} gab.com Text Genome-editing tools for stem cell biology JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=26203860 #FOAvip Human pluripotent stem cells provide a versatile platform for regenerative studies, drug testing and disease modeling. That the expression of only four transcription factors, Oct4, Klf4, Sox2 and c-Myc (OKSM), is sufficient for generation of induced pluripotent stem cells (iPSCs) from differentiated somatic cells has revolutionized the field and also highlighted the importance of OKSM as targets for genome editing. A number of novel genome-editing systems have been developed recently. In this review, we focus on successful applications of several such systems for generation of iPSCs. In particular, we discuss genome-editing systems based on zinc-finger fusion proteins (ZFs), transcription activator-like effectors (TALEs) and an RNA-guided DNA-specific nuclease, Cas9, derived from the bacterial defense system against viruses that utilizes clustered regularly interspaced short palindromic repeats (CRISPR). Twit Text FOAVip Genome-editing tools for stem cell biology ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=26203860 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26203860 #FOAvip English Wikipedia <ref>{{Cite pmid|26203860}}</ref> Genome-editing tools for stem cell biology #MMPMID26203860 Vasileva EA; Shuvalov OU; Garabadgiu AV; Melino G; Barlev NA Cell Death Dis 2015[Jul]; 6 (7): e1831- PMID26203860show ga Human pluripotent stem cells provide a versatile platform for regenerative studies, drug testing and disease modeling. That the expression of only four transcription factors, Oct4, Klf4, Sox2 and c-Myc (OKSM), is sufficient for generation of induced pluripotent stem cells (iPSCs) from differentiated somatic cells has revolutionized the field and also highlighted the importance of OKSM as targets for genome editing. A number of novel genome-editing systems have been developed recently. In this review, we focus on successful applications of several such systems for generation of iPSCs. In particular, we discuss genome-editing systems based on zinc-finger fusion proteins (ZFs), transcription activator-like effectors (TALEs) and an RNA-guided DNA-specific nuclease, Cas9, derived from the bacterial defense system against viruses that utilizes clustered regularly interspaced short palindromic repeats (CRISPR). äGenome-editing tools for stem cell biology (epmc).pdf DeepDyve Pubget Overpricing