Discovery of the migrasome, an organelle mediating release of cytoplasmic
contents during cell migration
#MMPMID25342562
Ma L
; Li Y
; Peng J
; Wu D
; Zhao X
; Cui Y
; Chen L
; Yan X
; Du Y
; Yu L
Cell Res
2015[Jan]; 25
(1
): 24-38
PMID25342562
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Cells communicate with each other through secreting and releasing proteins and
vesicles. Many cells can migrate. In this study, we report the discovery of
migracytosis, a cell migration-dependent mechanism for releasing cellular
contents, and migrasomes, the vesicular structures that mediate migracytosis. As
migrating cells move, they leave long tubular strands, called retraction fibers,
behind them. Large vesicles, which contain numerous smaller vesicles, grow on the
tips and intersections of retraction fibers. These fibers, which connect the
vesicles with the main cell body, eventually break, and the vesicles are released
into the extracellular space or directly taken up by surrounding cells. Since the
formation of these vesicles is migration-dependent, we named them "migrasomes".
We also found that cytosolic contents can be transported into migrasomes and
released from the cell through migrasomes. We named this migration-dependent
release mechanism "migracytosis".
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