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10.1038/cddis.2015.74 http://scihub22266oqcxt.onion/10.1038/cddis.2015.74 C4650543!4650543!25837484     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Dis 2015 ; 6 (4): e1708- Nephropedia Template TP {{tp|p=25837484|t=2015. Negative feedback loop between p66Shc and ZEB1 regulates fibrotic EMT response in lung cancer cells |pdf=|usr=}}{{25837484}} gab.com Text Negative feedback loop between p66Shc and ZEB1 regulates fibrotic EMT response in lung cancer cells JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=25837484 #FOAvip The epithelial-to-mesenchymal transition (EMT) program is crucial for the epithelial cancer progression and fibrotic diseases. Our previous work has demonstrated that p66Shc, a focal adhesion-associated adaptor protein, is frequently downregulated in lung cancers and its depletion promotes metastasis behavior through anoikis resistance. However, mechanism underlying loss of p66Shc and EMT response is not fully understood. Here, we showed that p66Shc deficiency enhanced the expression of ZEB1, the known mesenchymal transcription factor and consequently increased Vimentin, and decreased epithelial markers of E-cadherin and ?-catenin. p66Shc depletion also increased cell invasion and migration. In addition, ChIP and luciferase assays showed that these effects were directly mediated by ZEB1 repression of p66Shc promoter. Thus, our findings define a critical role of p66Shc in the suppression of fibrotic EMT response with a negative feedback loop between p66Shc and ZEB1 in lung epithelial cancer cells. Twit Text FOAVip Negative feedback loop between p66Shc and ZEB1 regulates fibrotic EMT response in lung cancer cells ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=25837484 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25837484 #FOAvip English Wikipedia <ref>{{Cite pmid|25837484}}</ref> Negative feedback loop between p66Shc and ZEB1 regulates fibrotic EMT response in lung cancer cells #MMPMID25837484 Li X; Gao D; Wang H; Li X; Yang J; Yan X; Liu Z; Ma Z Cell Death Dis 2015[Apr]; 6 (4): e1708- PMID25837484show ga The epithelial-to-mesenchymal transition (EMT) program is crucial for the epithelial cancer progression and fibrotic diseases. Our previous work has demonstrated that p66Shc, a focal adhesion-associated adaptor protein, is frequently downregulated in lung cancers and its depletion promotes metastasis behavior through anoikis resistance. However, mechanism underlying loss of p66Shc and EMT response is not fully understood. Here, we showed that p66Shc deficiency enhanced the expression of ZEB1, the known mesenchymal transcription factor and consequently increased Vimentin, and decreased epithelial markers of E-cadherin and ?-catenin. p66Shc depletion also increased cell invasion and migration. In addition, ChIP and luciferase assays showed that these effects were directly mediated by ZEB1 repression of p66Shc promoter. Thus, our findings define a critical role of p66Shc in the suppression of fibrotic EMT response with a negative feedback loop between p66Shc and ZEB1 in lung epithelial cancer cells. äNegative feedback loop between p66Shc and ZEB1 regulates fibrotic EMT (epmc).pdf DeepDyve Pubget Overpricing