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2015 ; 17
(2
): 206-11
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Testosterone therapy in men with prostate cancer: literature review, clinical
experience, and recommendations
#MMPMID25652633
Morgentaler A 3rd
; Conners WP
Asian J Androl
2015[Mar]; 17
(2
): 206-11
PMID25652633
show ga
For several decades any diagnosis of prostate cancer (PCa) has been considered an
absolute contraindication to the use of testosterone (T) therapy in men. Yet this
prohibition against T therapy has undergone recent re-examination with refinement
of our understanding of the biology of androgens and PCa, and increased
appreciation of the benefits of T therapy. A reassuringly low rate of negative
outcomes has been reported with T therapy after radical prostatectomy (RP),
radiation treatments, and in men on active surveillance. Although the number of
these published reports are few and the total number of treated men is low, these
experiences do provide a basis for consideration of T therapy in selected men
with PCa. For clinicians considering offering this treatment, we recommend first
selecting patients with low grade cancers and undetectable prostate-specific
antigen following RP. Further research is required to define the safety of T
therapy in men with PCa. However, many patients symptomatic from T deficiency are
willing to accept the potential risk of PCa progression or recurrence in return
for the opportunity to live a fuller and happier life with T therapy.