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2015 ; 17
(2
): 319-23
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The secretory products of Trichomonas vaginalis decrease fertilizing capacity of
mice sperm in vitro
#MMPMID25578937
Roh J
; Lim YS
; Seo MY
; Choi Y
; Ryu JS
Asian J Androl
2015[Mar]; 17
(2
): 319-23
PMID25578937
show ga
Trichomonas vaginalis infection is one of the most prevalent sexually transmitted
infections in humans and is now recognized as an important cause of infertility
in men. There is little information about the effect of extracellular polymeric
substances (EPS) from T. vaginalis on sperm, but previous reports do not provide
a conclusive description of the functional integrity of the sperm. To investigate
the impact of EPS on the fertilizing capacity of sperm, we assessed sperm
motility, acrosomal status, hypo-osmotic swelling, and in vitrofertilization rate
after incubating the sperm with EPS in vitrousing mice. The incubation of sperm
with EPS significantly decreased sperm motility, viability, and functional
integrity in a concentration and time-dependent manner. These effects on sperm
quality also resulted in a decreased fertilization rate in vitro. This is the
first report that demonstrates the direct negative impact of the EPS of T.
vaginalis on the fertilization rate of sperm in vitro. However, further study
should be performed using human sperm to determine if EPS has similar negative
impact on human sperm fertilizing capacity in vitro.