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10.1186/s13098-015-0097-1 http://scihub22266oqcxt.onion/10.1186/s13098-015-0097-1 C4650109!4650109!26583047     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetol+Metab+Syndr 2015 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26583047|t=2015. Progesterone ameliorates diabetic nephropathy in streptozotocin-induced diabetic Rats |pdf=|usr=}}{{26583047}} gab.com Text Progesterone ameliorates diabetic nephropathy in streptozotocin-induced diabetic Rats JO: Diabetol Metab Syndr http://www.kidney.de/pget.php?&tw=1&pmid=26583047 #FOAvip Background: Previous studies reported that 17?-estradiol may influence the progression of diabetic renal disease in females. The present study was intended to provide an insight into the specific effects of progesterone, the other female sex hormone, in the diabetic renal complications. Methods: Adult female wistar rats were divided into four groups (n = 6/group): intact control (non-diabetic, ND), intact diabetic (D), ovariectomized diabetic (D-OVX) and ovariectomized diabetic which were treated with progesterone (D-OVX + P; 10 mg/kg, s.c, every second day) for 10 weeks. Diabetes was induced by a single dose injection of 55 mg/kg streptozotocin. Expressions of transforming growth factor-? (TGF-?), fibronectin, vascular endothelial growth factor-A (VEGF-A), angiotensin II type 1 receptor (ATR1) and podocyte markers (nephrin and podocin) were assessed by immunohistochemistry and real-time PCR. Results: The treatment of D-OVX rats with progesterone attenuated diabetic-associated increases in the urinary albumin to creatinine ratio, glomerulosclerosi and the expression of profibrotic and angiogenic factors (TGF-?, Fibronectin and VEGF-A). Furthermore, progesterone supplementation prevented diabetes-induced downregulation of nephrin and podocin while the overexpression of ATR1 in the diabetic rats was inhibited by the progesterone supplementation. Conclusion: These results provided evidence, for the first time, that the replacement of progesterone can ameliorate the renal damage in the experimental models of diabetic nephropathy through improving the renal function; the inhibition of renal fibrosis and abnormal angiogenesis; along with the amelioration of podocyte injury. Additionally, the blocking of renin-angiotensin system through the down-regulation of ATR1 expression may also account for the reno-protective effect of progesterone. Electronic supplementary material: The online version of this article (doi:10.1186/s13098-015-0097-1) contains supplementary material, which is available to authorized users. Twit Text FOAVip Progesterone ameliorates diabetic nephropathy in streptozotocin-induced diabetic Rats ????Diabetol Metab Syndr http://www.kidney.de/pget.php?&tw=1&pmid=26583047 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26583047 #FOAvip English Wikipedia <ref>{{Cite pmid|26583047}}</ref> Progesterone ameliorates diabetic nephropathy in streptozotocin-induced diabetic Rats #MMPMID26583047 Al-Trad B; Ashankyty IM; Alaraj M Diabetol Metab Syndr 2015[]; 7 (ä): ä PMID26583047show ga Background: Previous studies reported that 17?-estradiol may influence the progression of diabetic renal disease in females. The present study was intended to provide an insight into the specific effects of progesterone, the other female sex hormone, in the diabetic renal complications. Methods: Adult female wistar rats were divided into four groups (n = 6/group): intact control (non-diabetic, ND), intact diabetic (D), ovariectomized diabetic (D-OVX) and ovariectomized diabetic which were treated with progesterone (D-OVX + P; 10 mg/kg, s.c, every second day) for 10 weeks. Diabetes was induced by a single dose injection of 55 mg/kg streptozotocin. Expressions of transforming growth factor-? (TGF-?), fibronectin, vascular endothelial growth factor-A (VEGF-A), angiotensin II type 1 receptor (ATR1) and podocyte markers (nephrin and podocin) were assessed by immunohistochemistry and real-time PCR. Results: The treatment of D-OVX rats with progesterone attenuated diabetic-associated increases in the urinary albumin to creatinine ratio, glomerulosclerosi and the expression of profibrotic and angiogenic factors (TGF-?, Fibronectin and VEGF-A). Furthermore, progesterone supplementation prevented diabetes-induced downregulation of nephrin and podocin while the overexpression of ATR1 in the diabetic rats was inhibited by the progesterone supplementation. Conclusion: These results provided evidence, for the first time, that the replacement of progesterone can ameliorate the renal damage in the experimental models of diabetic nephropathy through improving the renal function; the inhibition of renal fibrosis and abnormal angiogenesis; along with the amelioration of podocyte injury. Additionally, the blocking of renin-angiotensin system through the down-regulation of ATR1 expression may also account for the reno-protective effect of progesterone. Electronic supplementary material: The online version of this article (doi:10.1186/s13098-015-0097-1) contains supplementary material, which is available to authorized users. äProgesterone ameliorates diabetic nephropathy in streptozotocin-induce(epmc).pdf DeepDyve Pubget Overpricing