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10.1038/srep16900 http://scihub22266oqcxt.onion/10.1038/srep16900 C4649630!4649630 !26576741     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26576741 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26576741 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 16900 Nephropedia Template TP {{tp|p=26576741 |t=2015. p53/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis |pdf=|usr=}}{{26576741 }} gab.com Text p53/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26576741 #FOAvip Phagocytosis of SiO2 into the lung causes an inflammatory cascade that results in fibroblast proliferation and migration, followed by fibrosis. Clinical evidence has indicated that the activation of alveolar macrophages by SiO2 produces rapid and sustained inflammation characterized by the generation of monocyte chemotactic protein 1, which, in turn, induces fibrosis. However, the details of events downstream of monocyte chemotactic protein 1 activity in pulmonary fibroblasts remain unclear. Here, to elucidate the role of p53 in fibrosis induced by silica, both the upstream molecular mechanisms and the functional effects on cell proliferation and migration were investigated. Experiments using primary cultured adult human pulmonary fibroblasts led to the following results: 1) SiO2 treatment resulted in a rapid and sustained increase in p53 and PUMA protein levels; 2) the MAPK and PI3K pathways were involved in the SiO2-induced alteration of p53 and PUMA expression; and 3) RNA interference targeting p53 and PUMA prevented the SiO2-induced increases in fibroblast activation and migration. Our study elucidated a link between SiO2-induced p53/PUMA expression in fibroblasts and cell migration, thereby providing novel insight into the potential use of p53/PUMA in the development of novel therapeutic strategies for silicosis treatment. Twit Text FOAVip p53/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26576741 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26576741 #FOAvip English Wikipedia <ref>{{Cite pmid|26576741 }}</ref> p53/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis #MMPMID26576741 Wang W ; Liu H ; Dai X ; Fang S ; Wang X ; Zhang Y ; Yao H ; Zhang X ; Chao J Sci Rep 2015[Nov]; 5 (ä): 16900 PMID26576741 show ga Phagocytosis of SiO2 into the lung causes an inflammatory cascade that results in fibroblast proliferation and migration, followed by fibrosis. Clinical evidence has indicated that the activation of alveolar macrophages by SiO2 produces rapid and sustained inflammation characterized by the generation of monocyte chemotactic protein 1, which, in turn, induces fibrosis. However, the details of events downstream of monocyte chemotactic protein 1 activity in pulmonary fibroblasts remain unclear. Here, to elucidate the role of p53 in fibrosis induced by silica, both the upstream molecular mechanisms and the functional effects on cell proliferation and migration were investigated. Experiments using primary cultured adult human pulmonary fibroblasts led to the following results: 1) SiO2 treatment resulted in a rapid and sustained increase in p53 and PUMA protein levels; 2) the MAPK and PI3K pathways were involved in the SiO2-induced alteration of p53 and PUMA expression; and 3) RNA interference targeting p53 and PUMA prevented the SiO2-induced increases in fibroblast activation and migration. Our study elucidated a link between SiO2-induced p53/PUMA expression in fibroblasts and cell migration, thereby providing novel insight into the potential use of p53/PUMA in the development of novel therapeutic strategies for silicosis treatment. |*Gene Expression [MESH] |Apoptosis Regulatory Proteins/*genetics/metabolism [MESH] |Cell Movement/genetics [MESH] |Cell Survival/drug effects/genetics [MESH] |Collagen/metabolism [MESH] |Extracellular Matrix/metabolism [MESH] |Fibroblasts/*metabolism [MESH] |Gene Expression Regulation/drug effects [MESH] |Humans [MESH] |Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism [MESH] |Phosphatidylinositol 3-Kinases/metabolism [MESH] |Proto-Oncogene Proteins c-akt/antagonists & inhibitors/metabolism [MESH] |Proto-Oncogene Proteins/*genetics/metabolism [MESH] |RNA, Small Interfering/genetics [MESH] |Signal Transduction/drug effects [MESH] |Silicon Dioxide/adverse effects [MESH] |Silicosis/diagnosis/*etiology/metabolism [MESH] |Tomography, X-Ray Computed [MESH]p53/PUMA expression in human pulmonary fibroblasts mediates cell activ(epmc).pdf DeepDyve Pubget Overpricing