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10.1038/srep16859 http://scihub22266oqcxt.onion/10.1038/srep16859 C4649623!4649623 !26577912     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26577912 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 16859 Nephropedia Template TP {{tp|p=26577912 |t=2015. Peritoneal VEGF-A expression is regulated by TGF-?1 through an ID1 pathway in women with endometriosis |pdf=|usr=}}{{26577912 }} gab.com Text Peritoneal VEGF-A expression is regulated by TGF- 1 through an ID1 pathway in women with endometriosis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26577912 #FOAvip VEGF-A, an angiogenic factor, is increased in the peritoneal fluid of women with endometriosis. The cytokine TGF-?1 is thought to play a role in the establishment of endometriosis lesions. Inhibitor of DNA binding (ID) proteins are transcriptional targets of TGF-?1 and ID1 has been implicated in VEGF-A regulation during tumor angiogenesis. Herein, we determined whether peritoneal expression of VEGF-A is regulated by TGF-?1 through the ID1 pathway in women with endometriosis. VEGF-A was measured in peritoneal fluid by ELISA (n = 16). VEGF-A and ID1 expression was examined in peritoneal biopsies (n = 13), and primary peritoneal and immortalized mesothelial cells (MeT5A) by immunohistochemistry, qRT-PCR and ELISA. VEGF-A was increased in peritoneal fluid from women with endometriosis and levels correlated with TGF-?1 concentrations (P < 0.05). VEGF-A was immunolocalized to peritoneal mesothelium and TGF-?1 increased VEGFA mRNA (P < 0.05) and protein (P < 0.05) in mesothelial cells. ID1 was increased in peritoneum from women with endometriosis and TGF-?1 increased concentrations of ID1 mRNA (P < 0.05) in mesothelial cells. VEGF-A regulation through ID1 was confirmed by siRNA in MeT5A cells (P < 0.05). Our data supports role for ID1 in the pathophysiology of endometriosis, as an effector of TGF?1 dependent upregulation of VEGF-A, and highlights a novel potential therapeutic target. Twit Text FOAVip Peritoneal VEGF-A expression is regulated by TGF- 1 through an ID1 pathway in women with endometriosis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26577912 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26577912 #FOAvip English Wikipedia <ref>{{Cite pmid|26577912 }}</ref> Peritoneal VEGF-A expression is regulated by TGF-?1 through an ID1 pathway in women with endometriosis #MMPMID26577912 Young VJ ; Ahmad SF ; Brown JK ; Duncan WC ; Horne AW Sci Rep 2015[Nov]; 5 (ä): 16859 PMID26577912 show ga VEGF-A, an angiogenic factor, is increased in the peritoneal fluid of women with endometriosis. The cytokine TGF-?1 is thought to play a role in the establishment of endometriosis lesions. Inhibitor of DNA binding (ID) proteins are transcriptional targets of TGF-?1 and ID1 has been implicated in VEGF-A regulation during tumor angiogenesis. Herein, we determined whether peritoneal expression of VEGF-A is regulated by TGF-?1 through the ID1 pathway in women with endometriosis. VEGF-A was measured in peritoneal fluid by ELISA (n = 16). VEGF-A and ID1 expression was examined in peritoneal biopsies (n = 13), and primary peritoneal and immortalized mesothelial cells (MeT5A) by immunohistochemistry, qRT-PCR and ELISA. VEGF-A was increased in peritoneal fluid from women with endometriosis and levels correlated with TGF-?1 concentrations (P < 0.05). VEGF-A was immunolocalized to peritoneal mesothelium and TGF-?1 increased VEGFA mRNA (P < 0.05) and protein (P < 0.05) in mesothelial cells. ID1 was increased in peritoneum from women with endometriosis and TGF-?1 increased concentrations of ID1 mRNA (P < 0.05) in mesothelial cells. VEGF-A regulation through ID1 was confirmed by siRNA in MeT5A cells (P < 0.05). Our data supports role for ID1 in the pathophysiology of endometriosis, as an effector of TGF?1 dependent upregulation of VEGF-A, and highlights a novel potential therapeutic target. |*Gene Expression Regulation/drug effects [MESH] |*Signal Transduction [MESH] |Ascitic Fluid/metabolism [MESH] |Cells, Cultured [MESH] |Endometriosis/*genetics/*metabolism [MESH] |Female [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |Inhibitor of Differentiation Protein 1/genetics/*metabolism [MESH] |Peritoneum/cytology/metabolism [MESH] |RNA, Messenger/genetics/metabolism [MESH] |RNA, Small Interfering/genetics [MESH] |Transforming Growth Factor beta1/*metabolism/pharmacology [MESH]Peritoneal VEGF-A expression is regulated by TGF-?1 through an ID1 pat(epmc).pdf DeepDyve Pubget Overpricing