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10.1177/2040620715607415 http://scihub22266oqcxt.onion/10.1177/2040620715607415 C4649604!4649604!26622997     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ther+Adv+Hematol 2015 ; 6 (6): 282-94 Nephropedia Template TP {{tp|p=26622997|t=2015. Recent advances in the development of Aurora kinases inhibitors in hematological malignancies |pdf=|usr=}}{{26622997}} gab.com Text Recent advances in the development of Aurora kinases inhibitors in hematological malignancies JO: Ther Adv Hematol http://www.kidney.de/pget.php?&tw=1&pmid=26622997 #FOAvip Over the last two decades, since the discovery of Drosophila mutants in 1995, much effort has been made to understand Aurora kinase biology. Three mammalian subtypes have been identified thus far which include the Aurora A, B and C kinases. These regulatory proteins specifically work at the cytoskeleton and chromosomal structures between the kinetochores and have vital functions in the early phases of the mitotic cell cycle. Today, there are multiple phase I and phase II clinical trials as well as numerous preclinical studies taking place looking at Aurora kinase inhibitors in both hematologic and solid malignancies. This review focuses on the preclinical and clinical development of Aurora kinase inhibitors in hematological malignancy and discusses their therapeutic potential. Twit Text FOAVip Recent advances in the development of Aurora kinases inhibitors in hematological malignancies ????Ther Adv Hematol http://www.kidney.de/pget.php?&tw=1&pmid=26622997 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26622997 #FOAvip English Wikipedia <ref>{{Cite pmid|26622997}}</ref> Recent advances in the development of Aurora kinases inhibitors in hematological malignancies #MMPMID26622997 Choudary I; Barr PM; Friedberg J Ther Adv Hematol 2015[Dec]; 6 (6): 282-94 PMID26622997show ga Over the last two decades, since the discovery of Drosophila mutants in 1995, much effort has been made to understand Aurora kinase biology. Three mammalian subtypes have been identified thus far which include the Aurora A, B and C kinases. These regulatory proteins specifically work at the cytoskeleton and chromosomal structures between the kinetochores and have vital functions in the early phases of the mitotic cell cycle. Today, there are multiple phase I and phase II clinical trials as well as numerous preclinical studies taking place looking at Aurora kinase inhibitors in both hematologic and solid malignancies. This review focuses on the preclinical and clinical development of Aurora kinase inhibitors in hematological malignancy and discusses their therapeutic potential. äRecent advances in the development of Aurora kinases inhibitors in hem(epmc).pdf DeepDyve Pubget Overpricing