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10.1038/cddis.2014.450 http://scihub22266oqcxt.onion/10.1038/cddis.2014.450 C4649531!4649531!25356863     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Dis 2014 ; 5 (10): e1494- Nephropedia Template TP {{tp|p=25356863|t=2014. Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns |pdf=|usr=}}{{25356863}} gab.com Text Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=25356863 #FOAvip Apoptosis, which is anti-inflammatory, and necrosis, which is pro-inflammatory, represent the extremes of the cell death spectrum. Cell death is complex and both apoptosis and necrosis can be observed in the same cells or tissues. Here, we introduce a novel combined mode of cellular demise ? caspase-dependent regulated necrosis. Most importantly, it is mainly characterized with release of marked amount of oligo- or poly-nucleosomes and their attached damage-associated molecular patterns (DAMPs) and initiated by caspase activation. Caspase-activated DNase has dual roles in nucleosomal release as it can degrade extracellularly released chromatin into poly- or oligo-nucleosomes although it prohibits release of nucleosomes. In addition, osmotically triggered water movement following Cl? influx and subsequent Na+ influx appears to be the major driving force for nucleosomal and DAMPs release. Finally, Ca2+-activated cysteine protease, calpain, is an another essential factor in nucleosomal and DAMPs release because of complete reversion to apoptotic morphology from necrotic one and blockade of nucleosomal and DAMPs release by its inhibition. Twit Text FOAVip Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=25356863 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25356863 #FOAvip English Wikipedia <ref>{{Cite pmid|25356863}}</ref> Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns #MMPMID25356863 Yoon S; Park SJ; Han JH; Kang JH; Kim Jh; Lee J; Park S; Shin HJ; Kim K; Yun M; Chwae YJ Cell Death Dis 2014[Oct]; 5 (10): e1494- PMID25356863show ga Apoptosis, which is anti-inflammatory, and necrosis, which is pro-inflammatory, represent the extremes of the cell death spectrum. Cell death is complex and both apoptosis and necrosis can be observed in the same cells or tissues. Here, we introduce a novel combined mode of cellular demise ? caspase-dependent regulated necrosis. Most importantly, it is mainly characterized with release of marked amount of oligo- or poly-nucleosomes and their attached damage-associated molecular patterns (DAMPs) and initiated by caspase activation. Caspase-activated DNase has dual roles in nucleosomal release as it can degrade extracellularly released chromatin into poly- or oligo-nucleosomes although it prohibits release of nucleosomes. In addition, osmotically triggered water movement following Cl? influx and subsequent Na+ influx appears to be the major driving force for nucleosomal and DAMPs release. Finally, Ca2+-activated cysteine protease, calpain, is an another essential factor in nucleosomal and DAMPs release because of complete reversion to apoptotic morphology from necrotic one and blockade of nucleosomal and DAMPs release by its inhibition. äCaspase-dependent cell death-associated release of nucleosome and dama(epmc).pdf DeepDyve Pubget Overpricing