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10.1128/AAC.01476-15 http://scihub22266oqcxt.onion/10.1128/AAC.01476-15 C4649170!4649170!26349831     free     free     free       Antimicrob+Agents+Chemother 2015 ; 59 (12): 7786-9 Nephropedia Template TP {{tp|p=26349831|t=2015. Eagle Effect in Nonreplicating Persister Mycobacteria |pdf=|usr=}}{{26349831}} gab.com Text Eagle Effect in Nonreplicating Persister Mycobacteria JO: Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=26349831 #FOAvip We determined the microbicidal activities of antibacterials against nonreplicating Mycobacterium smegmatis grown in a starvation-based Loebel model for persistence. Whereas most drugs lost their activity, fluoroquinolones retained lethal potency. Dose-response characterizations showed a paradoxical more-drug-kills-less Eagle effect. Pretreatment of cultures with chloramphenicol blocked the lethal action of the gyrase inhibitors. These results suggest that fluoroquinolones at low concentrations trigger a protein synthesis-dependent cell death pathway and shut off this suicide pathway at elevated concentrations. Twit Text FOAVip Eagle Effect in Nonreplicating Persister Mycobacteria ????Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=26349831 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26349831 #FOAvip English Wikipedia <ref>{{Cite pmid|26349831}}</ref> Eagle Effect in Nonreplicating Persister Mycobacteria #MMPMID26349831 Wu ML; Tan J; Dick T Antimicrob Agents Chemother 2015[Dec]; 59 (12): 7786-9 PMID26349831show ga We determined the microbicidal activities of antibacterials against nonreplicating Mycobacterium smegmatis grown in a starvation-based Loebel model for persistence. Whereas most drugs lost their activity, fluoroquinolones retained lethal potency. Dose-response characterizations showed a paradoxical more-drug-kills-less Eagle effect. Pretreatment of cultures with chloramphenicol blocked the lethal action of the gyrase inhibitors. These results suggest that fluoroquinolones at low concentrations trigger a protein synthesis-dependent cell death pathway and shut off this suicide pathway at elevated concentrations. äEagle Effect in Nonreplicating Persister Mycobacteria (epmc).pdf DeepDyve Pubget Overpricing