Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26455414
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Stem+Cell+Reports
2015 ; 5
(5
): 690-701
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Different Motile Behaviors of Human Hematopoietic Stem versus Progenitor Cells at
the Osteoblastic Niche
#MMPMID26455414
Foster K
; Lassailly F
; Anjos-Afonso F
; Currie E
; Rouault-Pierre K
; Bonnet D
Stem Cell Reports
2015[Nov]; 5
(5
): 690-701
PMID26455414
show ga
Despite advances in our understanding of interactions between mouse hematopoietic
stem cells (HSCs) and their niche, little is known about communication between
human HSCs and the microenvironment. Using a xenotransplantation model and
intravital imaging, we demonstrate that human HSCs display distinct motile
behaviors to their hematopoietic progenitor cell (HPC) counterparts, and the same
pattern can be found between mouse HSCs and HPCs. HSCs become significantly less
motile after transplantation, while progenitor cells remain motile. We show that
human HSCs take longer to find their niche than previously expected and suggest
that the niche be defined as the position where HSCs stop moving. Intravital
imaging is the only technique to determine where in the bone marrow stem cells
stop moving, and future analyses should focus on the environment surrounding the
HSC at this point.