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10.1128/MCB.00579-15 http://scihub22266oqcxt.onion/10.1128/MCB.00579-15 C4648824!4648824 !26416883     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26416883 &cmd=llinks): Failed to open stream: HTTP request failed! 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Mild Glucose Starvation Induces KDM2A-Mediated H3K36me2 Demethylation through AMPK To Reduce rRNA Transcription and Cell Proliferation |pdf=|usr=}}{{26416883 }} gab.com Text Mild Glucose Starvation Induces KDM2A-Mediated H3K36me2 Demethylation through AMPK To Reduce rRNA Transcription and Cell Proliferation JO: Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26416883 #FOAvip Environmental conditions control rRNA transcription. Previously, we found that serum and glucose deprivation induces KDM2A-mediated H3K36me2 demethylation in the rRNA gene (rDNA) promoter and reduces rRNA transcription in the human breast cancer cell line MCF-7. However, the molecular mechanism and biological significance are still unclear. In the present study, we found that glucose starvation alone induced the KDM2A-dependent reduction of rRNA transcription. The treatment of cells with 2-deoxy-d-glucose, an inhibitor of glycolysis, reduced rRNA transcription and H3K36me2 in the rDNA promoter, both of which were completely dependent on KDM2A in low concentrations of 2-deoxy-d-glucose, that is, mild starvation conditions. The mild starvation induced these KDM2A activities through AMP-activated kinase (AMPK) but did not affect another AMPK effector of rRNA transcription, TIF-IA. In the triple-negative breast cancer cell line MDA-MB-231, the mild starvation also reduced rRNA transcription in a KDM2A-dependent manner. We detected KDM2A in breast cancer tissues irrespective of their estrogen receptor, progesterone receptor, and HER2 status, including triple-negative cancer tissues. In both MCF-7 and MDA-MB-231 cells, mild starvation reduced cell proliferation, and KDM2A knockdown suppressed the reduction of cell proliferation. These results suggest that under mild glucose starvation AMPK induces KDM2A-dependent reduction of rRNA transcription to control cell proliferation. Twit Text FOAVip Mild Glucose Starvation Induces KDM2A-Mediated H3K36me2 Demethylation through AMPK To Reduce rRNA Transcription and Cell Proliferation ????Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26416883 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26416883 #FOAvip English Wikipedia <ref>{{Cite pmid|26416883 }}</ref> Mild Glucose Starvation Induces KDM2A-Mediated H3K36me2 Demethylation through AMPK To Reduce rRNA Transcription and Cell Proliferation #MMPMID26416883 Tanaka Y ; Yano H ; Ogasawara S ; Yoshioka S ; Imamura H ; Okamoto K ; Tsuneoka M Mol Cell Biol 2015[Dec]; 35 (24 ): 4170-84 PMID26416883 show ga Environmental conditions control rRNA transcription. Previously, we found that serum and glucose deprivation induces KDM2A-mediated H3K36me2 demethylation in the rRNA gene (rDNA) promoter and reduces rRNA transcription in the human breast cancer cell line MCF-7. However, the molecular mechanism and biological significance are still unclear. In the present study, we found that glucose starvation alone induced the KDM2A-dependent reduction of rRNA transcription. The treatment of cells with 2-deoxy-d-glucose, an inhibitor of glycolysis, reduced rRNA transcription and H3K36me2 in the rDNA promoter, both of which were completely dependent on KDM2A in low concentrations of 2-deoxy-d-glucose, that is, mild starvation conditions. The mild starvation induced these KDM2A activities through AMP-activated kinase (AMPK) but did not affect another AMPK effector of rRNA transcription, TIF-IA. In the triple-negative breast cancer cell line MDA-MB-231, the mild starvation also reduced rRNA transcription in a KDM2A-dependent manner. We detected KDM2A in breast cancer tissues irrespective of their estrogen receptor, progesterone receptor, and HER2 status, including triple-negative cancer tissues. In both MCF-7 and MDA-MB-231 cells, mild starvation reduced cell proliferation, and KDM2A knockdown suppressed the reduction of cell proliferation. These results suggest that under mild glucose starvation AMPK induces KDM2A-dependent reduction of rRNA transcription to control cell proliferation. |AMP-Activated Protein Kinases/genetics/*metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/genetics [MESH] |DNA Methylation/genetics [MESH] |Deoxyglucose/pharmacology [MESH] |F-Box Proteins/genetics/*metabolism [MESH] |Glucose/metabolism [MESH] |Glycolysis/drug effects [MESH] |Histones/*metabolism [MESH] |Humans [MESH] |Jumonji Domain-Containing Histone Demethylases/genetics/*metabolism [MESH] |MCF-7 Cells [MESH] |Pol1 Transcription Initiation Complex Proteins/metabolism [MESH] |Promoter Regions, Genetic/genetics [MESH] |RNA Interference [MESH] |RNA, Ribosomal/genetics [MESH] |RNA, Small Interfering [MESH] |Starvation/*metabolism [MESH] |Transcription, Genetic/genetics [MESH]Mild Glucose Starvation Induces KDM2A-Mediated H3K36me2 Demethylation (epmc).pdf DeepDyve Pubget Overpricing