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10.1038/jid.2015.334 http://scihub22266oqcxt.onion/10.1038/jid.2015.334 C4648714!4648714!26399696     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Invest+Dermatol 2015 ; 135 (12): 2944-54 Nephropedia Template TP {{tp|p=26399696|t=2015. MCPIP1 regulates fibroblast migration in 3D collagen matrices downstream of MAP kinases and NF-?B |pdf=|usr=}}{{26399696}} gab.com Text MCPIP1 regulates fibroblast migration in 3D collagen matrices downstream of MAP kinases and NF- B JO: J Invest Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=26399696 #FOAvip The fibroblast-populated 3D collagen matrix has been used to model matrix contraction, cell motility, and general fibroblast biology. MCPIP1 (monocyte chemotactic protein-induced protein 1) has been shown to regulate inflammation, angiogenesis, and cellular motility. In the present study, we demonstrated induction of MCPIP1 in human fibroblasts embedded in the stress-released 3D collagen matrix, which occurred through activation of mitogen-activated protein kinases, phosphoinositide 3-kinase, and NF-?B. Furthermore, MCPIP1 induction was associated with inhibition of fibroblast migration out of the nested collagen matrix. MCPIP1 induction or ectopic expression also upregulated p53. RNA interference of p53 prevented the inhibition of migration produced by induction or ectopic expression of MCPIP1. Our findings suggest a new role for MCPIP1 as a molecular switch that regulates fibroblast migration in the nested collagen matrix model. Twit Text FOAVip MCPIP1 regulates fibroblast migration in 3D collagen matrices downstream of MAP kinases and NF- B ????J Invest Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=26399696 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26399696 #FOAvip English Wikipedia <ref>{{Cite pmid|26399696}}</ref> MCPIP1 regulates fibroblast migration in 3D collagen matrices downstream of MAP kinases and NF-?B #MMPMID26399696 Chao J; Dai X; Peņa T; Doyle DA; Guenther TM; Carlson MA J Invest Dermatol 2015[Dec]; 135 (12): 2944-54 PMID26399696show ga The fibroblast-populated 3D collagen matrix has been used to model matrix contraction, cell motility, and general fibroblast biology. MCPIP1 (monocyte chemotactic protein-induced protein 1) has been shown to regulate inflammation, angiogenesis, and cellular motility. In the present study, we demonstrated induction of MCPIP1 in human fibroblasts embedded in the stress-released 3D collagen matrix, which occurred through activation of mitogen-activated protein kinases, phosphoinositide 3-kinase, and NF-?B. Furthermore, MCPIP1 induction was associated with inhibition of fibroblast migration out of the nested collagen matrix. MCPIP1 induction or ectopic expression also upregulated p53. RNA interference of p53 prevented the inhibition of migration produced by induction or ectopic expression of MCPIP1. Our findings suggest a new role for MCPIP1 as a molecular switch that regulates fibroblast migration in the nested collagen matrix model. äMCPIP1 regulates fibroblast migration in 3D collagen matrices downstre(epmc).pdf DeepDyve Pubget Overpricing