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10.1038/srep07695 http://scihub22266oqcxt.onion/10.1038/srep07695 C4648347!4648347 !25573828     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25573828 &cmd=llinks): Failed to open stream: HTTP request failed! 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Palladin is upregulated in kidney disease and contributes to epithelial cell migration after injury |pdf=|usr=}}{{25573828 }} gab.com Text Palladin is upregulated in kidney disease and contributes to epithelial cell migration after injury JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=25573828 #FOAvip Recovery from acute kidney injury involving tubular epithelial cells requires proliferation and migration of healthy cells to the area of injury. In this study, we show that palladin, a previously characterized cytoskeletal protein, is upregulated in injured tubules and suggest that one of its functions during repair is to facilitate migration of remaining cells to the affected site. In a mouse model of anti-neutrophilic cytoplasmic antibody involving both tubular and glomerular disease, palladin is upregulated in injured tubular cells, crescents and capillary cells with angiitis. In human biopsies of kidneys from patients with other kidney diseases, palladin is also upregulated in crescents and injured tubules. In LLC-PK1 cells, a porcine proximal tubule cell line, stress induced by transforming growth factor-?1 (TGF-?1) leads to palladin upregulation. Knockdown of palladin in LLC-PK1 does not disrupt cell morphology but does lead to a defect in cell migration. Furthermore, TGF-?1 induced increase in the 75 kDa palladin isoform occurs in both the nucleus and the cytoplasm. These data suggest that palladin expression is induced in injured cells and contributes to proper migration of cells in proximal tubules, possibly by regulation of gene expression as part of the healing process after acute injury. Twit Text FOAVip Palladin is upregulated in kidney disease and contributes to epithelial cell migration after injury ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=25573828 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25573828 #FOAvip English Wikipedia <ref>{{Cite pmid|25573828 }}</ref> Palladin is upregulated in kidney disease and contributes to epithelial cell migration after injury #MMPMID25573828 Chang EH ; Gasim AH ; Kerber ML ; Patel JB ; Glaubiger SA ; Falk RJ ; Jennette JC ; Otey CA Sci Rep 2015[Jan]; 5 (ä): 7695 PMID25573828 show ga Recovery from acute kidney injury involving tubular epithelial cells requires proliferation and migration of healthy cells to the area of injury. In this study, we show that palladin, a previously characterized cytoskeletal protein, is upregulated in injured tubules and suggest that one of its functions during repair is to facilitate migration of remaining cells to the affected site. In a mouse model of anti-neutrophilic cytoplasmic antibody involving both tubular and glomerular disease, palladin is upregulated in injured tubular cells, crescents and capillary cells with angiitis. In human biopsies of kidneys from patients with other kidney diseases, palladin is also upregulated in crescents and injured tubules. In LLC-PK1 cells, a porcine proximal tubule cell line, stress induced by transforming growth factor-?1 (TGF-?1) leads to palladin upregulation. Knockdown of palladin in LLC-PK1 does not disrupt cell morphology but does lead to a defect in cell migration. Furthermore, TGF-?1 induced increase in the 75 kDa palladin isoform occurs in both the nucleus and the cytoplasm. These data suggest that palladin expression is induced in injured cells and contributes to proper migration of cells in proximal tubules, possibly by regulation of gene expression as part of the healing process after acute injury. |Acute Kidney Injury/metabolism/pathology [MESH] |Animals [MESH] |Cell Line [MESH] |Cell Movement/drug effects [MESH] |Cell Nucleus/metabolism [MESH] |Cytoplasm/metabolism [MESH] |Cytoskeletal Proteins/antagonists & inhibitors/genetics/*metabolism [MESH] |Epithelial Cells/cytology/metabolism [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Kidney Diseases/metabolism/pathology [MESH] |Kidney/pathology [MESH] |Mice [MESH] |Protein Isoforms/genetics/metabolism [MESH] |RNA Interference [MESH] |RNA, Small Interfering/metabolism [MESH] |Swine [MESH] |Transforming Growth Factor beta1/pharmacology [MESH]Palladin is upregulated in kidney disease and contributes to epithelia(epmc).pdf DeepDyve Pubget Overpricing