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10.1038/cdd.2015.28 http://scihub22266oqcxt.onion/10.1038/cdd.2015.28 C4648326!4648326!25882046     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Differ 2015 ; 22 (11): 1792-802 Nephropedia Template TP {{tp|p=25882046|t=2015. Distinct requirements of Autophagy-related genes in programmed cell death |pdf=|usr=}}{{25882046}} gab.com Text Distinct requirements of Autophagy-related genes in programmed cell death JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=25882046 #FOAvip Although most programmed cell death (PCD) during animal development occurs by caspase-dependent apoptosis, autophagy-dependent cell death is also important in specific contexts. In previous studies, we established that PCD of the obsolete Drosophila larval midgut tissue is dependent on autophagy and can occur in the absence of the main components of the apoptotic pathway. As autophagy is primarily a survival mechanism in response to stress such as starvation, it is currently unclear if the regulation and mechanism of autophagy as a pro-death pathway is distinct to that as pro-survival. To establish the requirement of the components of the autophagy pathway during cell death, we examined the effect of systematically knocking down components of the autophagy machinery on autophagy induction and timing of midgut PCD. We found that there is a distinct requirement of the individual components of the autophagy pathway in a pro-death context. Furthermore, we show that TORC1 is upstream of autophagy induction in the midgut indicating that while the machinery may be distinct the activation may occur similarly in PCD and during starvation-induced autophagy signalling. Our data reveal that while autophagy initiation occurs similarly in different cellular contexts, there is a tissue/function-specific requirement for the components of the autophagic machinery. Twit Text FOAVip Distinct requirements of Autophagy-related genes in programmed cell death ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=25882046 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25882046 #FOAvip English Wikipedia <ref>{{Cite pmid|25882046}}</ref> Distinct requirements of Autophagy-related genes in programmed cell death #MMPMID25882046 Xu T; Nicolson S; Denton D; Kumar S Cell Death Differ 2015[Nov]; 22 (11): 1792-802 PMID25882046show ga Although most programmed cell death (PCD) during animal development occurs by caspase-dependent apoptosis, autophagy-dependent cell death is also important in specific contexts. In previous studies, we established that PCD of the obsolete Drosophila larval midgut tissue is dependent on autophagy and can occur in the absence of the main components of the apoptotic pathway. As autophagy is primarily a survival mechanism in response to stress such as starvation, it is currently unclear if the regulation and mechanism of autophagy as a pro-death pathway is distinct to that as pro-survival. To establish the requirement of the components of the autophagy pathway during cell death, we examined the effect of systematically knocking down components of the autophagy machinery on autophagy induction and timing of midgut PCD. We found that there is a distinct requirement of the individual components of the autophagy pathway in a pro-death context. Furthermore, we show that TORC1 is upstream of autophagy induction in the midgut indicating that while the machinery may be distinct the activation may occur similarly in PCD and during starvation-induced autophagy signalling. Our data reveal that while autophagy initiation occurs similarly in different cellular contexts, there is a tissue/function-specific requirement for the components of the autophagic machinery. äDistinct requirements of Autophagy-related genes in programmed cell de(epmc).pdf DeepDyve Pubget Overpricing