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10.1038/cdd.2015.20 http://scihub22266oqcxt.onion/10.1038/cdd.2015.20 C4648322!4648322!25822341     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Differ 2015 ; 22 (11): 1742-53 Nephropedia Template TP {{tp|p=25822341|t=2015. Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy |pdf=|usr=}}{{25822341}} gab.com Text Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=25822341 #FOAvip Oxidative stress and mitochondrial failure are prominent factors in the axonal degeneration process. In this study, we demonstrate that sirtuin 1 (SIRT1), a key regulator of the mitochondrial function, is impaired in the axonopathy and peroxisomal disease X-linked adrenoleukodystrophy (X-ALD). We have restored SIRT1 activity using a dual strategy of resveratrol treatment or by the moderate transgenic overexpression of SIRT1 in a X-ALD mouse model. Both strategies normalized redox homeostasis, mitochondrial respiration, bioenergetic failure, axonal degeneration and associated locomotor disabilities in the X-ALD mice. These results indicate that the reactivation of SIRT1 may be a valuable strategy to treat X-ALD and other axonopathies in which the control of redox and energetic homeostasis is impaired. Twit Text FOAVip Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=25822341 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25822341 #FOAvip English Wikipedia <ref>{{Cite pmid|25822341}}</ref> Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy #MMPMID25822341 Morató L; Ruiz M; Boada J; Calingasan NY; Galino J; Guilera C; Jové M; Naudí A; Ferrer I; Pamplona R; Serrano M; Portero-Otín M; Beal MF; Fourcade S; Pujol A Cell Death Differ 2015[Nov]; 22 (11): 1742-53 PMID25822341show ga Oxidative stress and mitochondrial failure are prominent factors in the axonal degeneration process. In this study, we demonstrate that sirtuin 1 (SIRT1), a key regulator of the mitochondrial function, is impaired in the axonopathy and peroxisomal disease X-linked adrenoleukodystrophy (X-ALD). We have restored SIRT1 activity using a dual strategy of resveratrol treatment or by the moderate transgenic overexpression of SIRT1 in a X-ALD mouse model. Both strategies normalized redox homeostasis, mitochondrial respiration, bioenergetic failure, axonal degeneration and associated locomotor disabilities in the X-ALD mice. These results indicate that the reactivation of SIRT1 may be a valuable strategy to treat X-ALD and other axonopathies in which the control of redox and energetic homeostasis is impaired. äActivation of sirtuin 1 as therapy for the peroxisomal disease adrenol(epmc).pdf DeepDyve Pubget Overpricing