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10.1038/cdd.2015.18 http://scihub22266oqcxt.onion/10.1038/cdd.2015.18 C4648321!4648321!25744026     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25744026&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Differ 2015 ; 22 (11): 1754-63 Nephropedia Template TP {{tp|p=25744026|t=2015. Caspases shutdown nonsense-mediated mRNA decay during apoptosis |pdf=|usr=}}{{25744026}} gab.com Text Caspases shutdown nonsense-mediated mRNA decay during apoptosis JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=25744026 #FOAvip Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance mechanism that plays integral roles in eliminating mRNAs with premature termination codons to prevent the synthesis of truncated proteins that could be pathogenic. One response to the accumulation of detrimental proteins is apoptosis, which involves the activation of enzymatic pathways leading to protein and nucleic acid cleavage and culminating in cell death. It is not clear whether NMD is required to ensure the accurate expression of apoptosis genes or is no longer necessary since cytotoxic proteins are not an issue during cell death. The present study shows that caspases cleave the two NMD factors UPF1 and UPF2 during apoptosis impairing NMD. Our results demonstrate a new regulatory pathway for NMD that occurs during apoptosis and provide evidence for role of the UPF cleaved fragments in apoptosis and NMD inhibition. Twit Text FOAVip Caspases shutdown nonsense-mediated mRNA decay during apoptosis ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=25744026 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25744026 #FOAvip English Wikipedia <ref>{{Cite pmid|25744026}}</ref> Caspases shutdown nonsense-mediated mRNA decay during apoptosis #MMPMID25744026 Jia J; Furlan A; Gonzalez-Hilarion S; Leroy C; Gruenert DC; Tulasne D; Lejeune F Cell Death Differ 2015[Nov]; 22 (11): 1754-63 PMID25744026show ga Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance mechanism that plays integral roles in eliminating mRNAs with premature termination codons to prevent the synthesis of truncated proteins that could be pathogenic. One response to the accumulation of detrimental proteins is apoptosis, which involves the activation of enzymatic pathways leading to protein and nucleic acid cleavage and culminating in cell death. It is not clear whether NMD is required to ensure the accurate expression of apoptosis genes or is no longer necessary since cytotoxic proteins are not an issue during cell death. The present study shows that caspases cleave the two NMD factors UPF1 and UPF2 during apoptosis impairing NMD. Our results demonstrate a new regulatory pathway for NMD that occurs during apoptosis and provide evidence for role of the UPF cleaved fragments in apoptosis and NMD inhibition. äCaspases shutdown nonsense-mediated mRNA decay during apoptosis (epmc).pdf DeepDyve Pubget Overpricing