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10.1016/j.devcel.2014.09.005 http://scihub22266oqcxt.onion/10.1016/j.devcel.2014.09.005 C4648281!4648281 !25373780     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25373780 &cmd=llinks): Failed to open stream: HTTP request failed! 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A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression |pdf=|usr=}}{{25373780 }} gab.com Text A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression JO: Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=25373780 #FOAvip Understanding cells as integrated systems requires that we systematically decipher how single genes affect multiple biological processes and how processes are functionally linked. Here, we used multiprocess phenotypic profiling, combining high-resolution 3D confocal microscopy and multiparametric image analysis, to simultaneously survey the fission yeast genome with respect to three key cellular processes: cell shape, microtubule organization, and cell-cycle progression. We identify, validate, and functionally annotate 262 genes controlling specific aspects of those processes. Of these, 62% had not been linked to these processes before and 35% are implicated in multiple processes. Importantly, we identify a conserved role for DNA-damage responses in controlling microtubule stability. In addition, we investigate how the processes are functionally linked. We show unexpectedly that disruption of cell-cycle progression does not necessarily affect cell size control and that distinct aspects of cell shape regulate microtubules and vice versa, identifying important systems-level links across these processes. Twit Text FOAVip A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression ????Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=25373780 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25373780 #FOAvip English Wikipedia <ref>{{Cite pmid|25373780 }}</ref> A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression #MMPMID25373780 Graml V ; Studera X ; Lawson JLD ; Chessel A ; Geymonat M ; Bortfeld-Miller M ; Walter T ; Wagstaff L ; Piddini E ; Carazo Salas RE Dev Cell 2014[Oct]; 31 (2 ): 227-239 PMID25373780 show ga Understanding cells as integrated systems requires that we systematically decipher how single genes affect multiple biological processes and how processes are functionally linked. Here, we used multiprocess phenotypic profiling, combining high-resolution 3D confocal microscopy and multiparametric image analysis, to simultaneously survey the fission yeast genome with respect to three key cellular processes: cell shape, microtubule organization, and cell-cycle progression. We identify, validate, and functionally annotate 262 genes controlling specific aspects of those processes. Of these, 62% had not been linked to these processes before and 35% are implicated in multiple processes. Importantly, we identify a conserved role for DNA-damage responses in controlling microtubule stability. In addition, we investigate how the processes are functionally linked. We show unexpectedly that disruption of cell-cycle progression does not necessarily affect cell size control and that distinct aspects of cell shape regulate microtubules and vice versa, identifying important systems-level links across these processes. |Cell Cycle Proteins/genetics [MESH] |Cell Cycle/*genetics [MESH] |Cell Division [MESH] |Cell Shape/*genetics [MESH] |DNA Damage [MESH] |DNA Repair [MESH] |Fungal Proteins/genetics [MESH] |Gene Knockout Techniques [MESH] |Imaging, Three-Dimensional [MESH] |Microscopy, Confocal [MESH] |Microtubules/*genetics/physiology [MESH] |Protein Transport/genetics [MESH] |Schizosaccharomyces pombe Proteins/*genetics [MESH] |Schizosaccharomyces/cytology/genetics [MESH]A genomic Multiprocess survey of machineries that control and link cel(epmc).pdf DeepDyve Pubget Overpricing