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10.12688/f1000research.6754.1 http://scihub22266oqcxt.onion/10.12688/f1000research.6754.1 C4648190!4648190!26594351     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       F1000Res 2015 ; 4 (F1000 Faculty Rev): ä Nephropedia Template TP {{tp|p=26594351|t=2015. Cytotoxic granule secretion by lymphocytes and its link to immune homeostasis |pdf=|usr=}}{{26594351}} gab.com Text Cytotoxic granule secretion by lymphocytes and its link to immune homeostasis JO: F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=26594351 #FOAvip The granule-dependent cytotoxic activity of T and natural killer lymphocytes has progressively emerged as an important effector pathway not only for host defence but also for immune regulation. The analysis of an early-onset, severe, primary immune dysregulatory syndrome known as hemophagocytic lymphohistiocytosis (HLH) has been decisive in highlighting this latter role and identifying key effectors on the basis of gene mutation analyses and mediators in the maturation and secretion of cytotoxic granules. Studies of cytotoxicity-deficient murine counterparts have helped to define primary HLH as a syndrome in which uncontrolled T-cell activation in response to lymphocytic choriomeningitis virus infection results in excessive macrophage activation and inflammation-associated cytopenia. Recent recognition of late-onset HLH, which occurs in a variety of settings, in association with hypomorphic, monoallelic mutations in genes encoding components of the granule-dependent cytotoxic pathway or even in the absence of such mutations has broadened our view about the mechanisms that underlie the perturbation of immune homeostasis. These findings have led to the development of a model in which disease occurs when a threshold is reached through the accumulation of genetic and environmental risk factors. Nevertheless, validation of this model will require further investigations. Twit Text FOAVip Cytotoxic granule secretion by lymphocytes and its link to immune homeostasis ????F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=26594351 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26594351 #FOAvip English Wikipedia <ref>{{Cite pmid|26594351}}</ref> Cytotoxic granule secretion by lymphocytes and its link to immune homeostasis #MMPMID26594351 de Saint Basile G; Sepulveda FE; Maschalidi S; Fischer A F1000Res 2015[]; 4 (F1000 Faculty Rev): ä PMID26594351show ga The granule-dependent cytotoxic activity of T and natural killer lymphocytes has progressively emerged as an important effector pathway not only for host defence but also for immune regulation. The analysis of an early-onset, severe, primary immune dysregulatory syndrome known as hemophagocytic lymphohistiocytosis (HLH) has been decisive in highlighting this latter role and identifying key effectors on the basis of gene mutation analyses and mediators in the maturation and secretion of cytotoxic granules. Studies of cytotoxicity-deficient murine counterparts have helped to define primary HLH as a syndrome in which uncontrolled T-cell activation in response to lymphocytic choriomeningitis virus infection results in excessive macrophage activation and inflammation-associated cytopenia. Recent recognition of late-onset HLH, which occurs in a variety of settings, in association with hypomorphic, monoallelic mutations in genes encoding components of the granule-dependent cytotoxic pathway or even in the absence of such mutations has broadened our view about the mechanisms that underlie the perturbation of immune homeostasis. These findings have led to the development of a model in which disease occurs when a threshold is reached through the accumulation of genetic and environmental risk factors. Nevertheless, validation of this model will require further investigations. äCytotoxic granule secretion by lymphocytes and its link to immune home(epmc).pdf DeepDyve Pubget Overpricing