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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Genes+Dev 2015 ; 29 (21): 2219-24 Nephropedia Template TP
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Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers #MMPMID26515115
Stern JL; Theodorescu D; Vogelstein B; Papadopoulos N; Cech TR
Genes Dev 2015[Nov]; 29 (21): 2219-24 PMID26515115show ga
Stern et al. found in multiple cancer cell lines that a TERT gene with a promoter mutation exhibits the H3K4me2/3 mark of active chromatin, while the wild-type allele retains the H3K27me3 mark of epigenetic silencing. Consistent with these differences, only the mutant promoters are transcriptionally active.