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10.1101/gad.269498.115

http://scihub22266oqcxt.onion/10.1101/gad.269498.115
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C4647555!4647555!26515115
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suck abstract from ncbi


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pmid26515115      Genes+Dev 2015 ; 29 (21): 2219-24
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  • Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers #MMPMID26515115
  • Stern JL; Theodorescu D; Vogelstein B; Papadopoulos N; Cech TR
  • Genes Dev 2015[Nov]; 29 (21): 2219-24 PMID26515115show ga
  • Stern et al. found in multiple cancer cell lines that a TERT gene with a promoter mutation exhibits the H3K4me2/3 mark of active chromatin, while the wild-type allele retains the H3K27me3 mark of epigenetic silencing. Consistent with these differences, only the mutant promoters are transcriptionally active.
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