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10.1101/gad.269498.115 http://scihub22266oqcxt.onion/10.1101/gad.269498.115 C4647555!4647555 !26515115     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26515115 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genes+Dev 2015 ; 29 (21 ): 2219-24 Nephropedia Template TP {{tp|p=26515115 |t=2015. Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers |pdf=|usr=}}{{26515115 }} gab.com Text Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=26515115 #FOAvip Somatic mutations in the promoter of the gene for telomerase reverse transcriptase (TERT) are the most common noncoding mutations in cancer. They are thought to activate telomerase, contributing to proliferative immortality, but the molecular events driving TERT activation are largely unknown. We observed in multiple cancer cell lines that mutant TERT promoters exhibit the H3K4me2/3 mark of active chromatin and recruit the GABPA/B1 transcription factor, while the wild-type allele retains the H3K27me3 mark of epigenetic silencing; only the mutant promoters are transcriptionally active. These results suggest how a single-base-pair mutation can cause a dramatic epigenetic switch and monoallelic expression. Twit Text FOAVip Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=26515115 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26515115 #FOAvip English Wikipedia <ref>{{Cite pmid|26515115 }}</ref> Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers #MMPMID26515115 Stern JL ; Theodorescu D ; Vogelstein B ; Papadopoulos N ; Cech TR Genes Dev 2015[Nov]; 29 (21 ): 2219-24 PMID26515115 show ga Somatic mutations in the promoter of the gene for telomerase reverse transcriptase (TERT) are the most common noncoding mutations in cancer. They are thought to activate telomerase, contributing to proliferative immortality, but the molecular events driving TERT activation are largely unknown. We observed in multiple cancer cell lines that mutant TERT promoters exhibit the H3K4me2/3 mark of active chromatin and recruit the GABPA/B1 transcription factor, while the wild-type allele retains the H3K27me3 mark of epigenetic silencing; only the mutant promoters are transcriptionally active. These results suggest how a single-base-pair mutation can cause a dramatic epigenetic switch and monoallelic expression. |*Gene Expression Regulation, Neoplastic [MESH] |Cell Line, Tumor [MESH] |Chromatin/genetics/*metabolism [MESH] |Epigenesis, Genetic/genetics [MESH] |GA-Binding Protein Transcription Factor/genetics/metabolism [MESH] |Gene Silencing [MESH] |Humans [MESH] |Mutation/*genetics [MESH] |Neoplasms/*genetics [MESH] |Promoter Regions, Genetic/*genetics [MESH] |Protein Binding [MESH]Mutation of the TERT promoter, switch to active chromatin, and monoall(epmc).pdf DeepDyve Pubget Overpricing