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10.1038/bjc.2015.192

http://scihub22266oqcxt.onion/10.1038/bjc.2015.192
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C4647523!4647523!26068397
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suck abstract from ncbi


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pmid26068397      Br+J+Cancer 2015 ; 113 (1): 6-11
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  • Best supportive care in clinical trials: review of the inconsistency in control arm design #MMPMID26068397
  • Nipp RD; Currow DC; Cherny NI; Strasser F; Abernethy AP; Zafar SY
  • Br J Cancer 2015[Jun]; 113 (1): 6-11 PMID26068397show ga
  • Background:: Best supportive care (BSC) as a control arm in clinical trials is poorly defined. We conducted a review to evaluate clinical trials' concordance with published, consensus-based framework for BSC delivery in trials. Methods:: A consensus-based Delphi panel previously identified four key domains of BSC delivery in trials: multidisciplinary care; supportive care documentation; symptom assessment; and symptom management. We reviewed trials including BSC control arms from 2002 to 2014 to assess concordance to BSC standards and to selected items from the CONSORT 2010 guidelines. Results:: Of 408 articles retrieved, we retained 18 after applying exclusion criteria. Overall, trials conformed to the CONSORT guidelines better than the BSC standards (28% vs 16%). One-third of articles offered a detailed description of BSC, 61% reported regular symptom assessment, and 44% reported using validated symptom assessment measures. One-third reported symptom assessment at identical intervals in both arms. None documented evidence-based symptom management. No studies reported educating patients about symptom management or goals of therapy. No studies reported offering access to palliative care specialists. Conclusions:: Reporting of BSC in trials is incomplete, resulting in uncertain internal and external validity. Such studies risk systematically over-estimating the net clinical effect of the comparator arms.
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