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10.1084/jem.20151069

http://scihub22266oqcxt.onion/10.1084/jem.20151069
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C4647269!4647269!26527800
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suck abstract from ncbi


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pmid26527800      J+Exp+Med 2015 ; 212 (12): 1993-2002
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  • Identification of a novel cis-regulatory element essential for immune tolerance #MMPMID26527800
  • LaFlam TN; Seumois G; Miller CN; Lwin W; Fasano KJ; Waterfield M; Proekt I; Vijayanand P; Anderson MS
  • J Exp Med 2015[Nov]; 212 (12): 1993-2002 PMID26527800show ga
  • LaFlam et al. identify a novel and highly conserved noncoding DNA element, ACNS1, essential for Aire expression and immune tolerance regulation in thymic epithelial cells. They show that ACNS1 is an NF-?B?responsive element and that its loss results in development of spontaneous autoimmunity in mice.
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