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10.1084/jem.20150792

http://scihub22266oqcxt.onion/10.1084/jem.20150792
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C4647266!4647266!26552706
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suck abstract from ncbi


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pmid26552706      J+Exp+Med 2015 ; 212 (12): 2165-82
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  • DNAM-1 controls NK cell activation via an ITT-like motif #MMPMID26552706
  • Zhang Z; Wu N; Lu Y; Davidson D; Colonna M; Veillette A
  • J Exp Med 2015[Nov]; 212 (12): 2165-82 PMID26552706show ga
  • DNAM-1­?mediated active biochemical signals initiated by a conserved ITT-like motif are essential for its capacity to enhance NK cell cytotoxicity and cytokine production. Enhancement of these signals may underlie the therapeutic impact of blocking anti-TIGIT antibodies for treatment of cancer and viral infections.
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