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10.1074/jbc.M115.692285

http://scihub22266oqcxt.onion/10.1074/jbc.M115.692285
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C4646034!4646034!26432639
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suck abstract from ncbi


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pmid26432639      J+Biol+Chem 2015 ; 290 (46): 27928-38
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  • TAZ Protein Accumulation Is Negatively Regulated by YAP Abundance in Mammalian Cells* #MMPMID26432639
  • Finch-Edmondson ML; Strauss RP; Passman AM; Sudol M; Yeoh GC; Callus BA
  • J Biol Chem 2015[Nov]; 290 (46): 27928-38 PMID26432639show ga
  • Background: Hippo pathway effectors YAP and TAZ are transcriptional coactivators that regulate cellular proliferation and tumorigenesis.Results: YAP negatively regulates TAZ abundance in a GSK-3-dependent manner.Conclusion: Changes in YAP abundance results in compensatory changes in TAZ to maintain Hippo signaling homeostasis.Significance: This initial reporting of a direct relationship between YAP and TAZ abundances has profound implications for understanding their biological functions.
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