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10.1074/jbc.M115.654129

http://scihub22266oqcxt.onion/10.1074/jbc.M115.654129
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C4646015!4646015!26432643
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suck abstract from ncbi


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pmid26432643      J+Biol+Chem 2015 ; 290 (46): 27644-59
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  • Subcellular Distribution of NAD+ between Cytosol and Mitochondria Determines the Metabolic Profile of Human Cells* #MMPMID26432643
  • VanLinden MR; Dölle C; Pettersen IKN; Kulikova VA; Niere M; Agrimi G; Dyrstad SE; Palmieri F; Nikiforov AA; Tronstad KJ; Ziegler M
  • J Biol Chem 2015[Nov]; 290 (46): 27644-59 PMID26432643show ga
  • Background: Maintaining the mitochondrial NAD+ pool is important, whereas its generation in mammalian cells is not understood.Results: A plant transporter expressed in human cells increases mitochondrial NAD+ but shifts metabolism from respiration to glycolysis.Conclusion: In human cells, NAD+ is synthesized in mitochondria rather than imported from the cytosol.Significance: Separation of subcellular NAD+ pools may be critical for metabolism in mammalian cells.
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