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10.1074/jbc.M115.675181 http://scihub22266oqcxt.onion/10.1074/jbc.M115.675181 C4646006!4646006!26434806     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2015 ; 290 (46): 27533-44 Nephropedia Template TP {{tp|p=26434806|t=2015. The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change* |pdf=|usr=}}{{26434806}} gab.com Text The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26434806 #FOAvip Background: Squalene monooxygenase (SM), a rate-limiting cholesterol synthesis enzyme, is degraded in conditions of excess cholesterol.Results: The cholesterol-regulatory domain of SM is membrane-associated by a re-entrant loop and undergoes a cholesterol-dependent conformational change.Conclusion: A cholesterol-induced conformational change appears to allow SM to be targeted for degradation.Significance: This is the first structural, mechanistic explanation for cholesterol-regulated SM degradation. Twit Text FOAVip The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26434806 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26434806 #FOAvip English Wikipedia <ref>{{Cite pmid|26434806}}</ref> The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change* #MMPMID26434806 Howe V; Chua NK; Stevenson J; Brown AJ J Biol Chem 2015[Nov]; 290 (46): 27533-44 PMID26434806show ga Background: Squalene monooxygenase (SM), a rate-limiting cholesterol synthesis enzyme, is degraded in conditions of excess cholesterol.Results: The cholesterol-regulatory domain of SM is membrane-associated by a re-entrant loop and undergoes a cholesterol-dependent conformational change.Conclusion: A cholesterol-induced conformational change appears to allow SM to be targeted for degradation.Significance: This is the first structural, mechanistic explanation for cholesterol-regulated SM degradation. äThe Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant (epmc).pdf DeepDyve Pubget Overpricing