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10.1074/jbc.M115.650028

http://scihub22266oqcxt.onion/10.1074/jbc.M115.650028
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C4645612!4645612!26245898
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suck abstract from ncbi


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pmid26245898      J+Biol+Chem 2015 ; 290 (38): 23050-63
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  • Hierarchal Autophagic Divergence of Hematopoietic System* #MMPMID26245898
  • Cao Y; Zhang S; Yuan N; Wang J; Li X; Xu F; Lin W; Song L; Fang Y; Wang Z; Wang Z; Zhang H; Zhang Y; Zhao W; Hu S; Zhang X; Wang J
  • J Biol Chem 2015[Sep]; 290 (38): 23050-63 PMID26245898show ga
  • Background: Autophagy is required in hematopoiesis and protects against leukemogenesis.Results: When ATG7-dependent canonical autophagy is impaired, ATG7-independent alternative autophagy engages in myeloid cells but not in hematopoietic stem cells.Conclusion: The integrity of hematopoietic stem cells is jeopardized by a lack of alternative autophagy.Significance: Learning autophagy organization in hematopoietic system is crucial for understanding hematopoietic stem cell transformation.
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