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10.1074/jbc.M115.664037

http://scihub22266oqcxt.onion/10.1074/jbc.M115.664037
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C4645610!4645610!26245897
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suck abstract from ncbi


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pmid26245897      J+Biol+Chem 2015 ; 290 (38): 23401-15
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  • Glioblastoma-derived Macrophage Colony-stimulating Factor (MCSF) Induces Microglial Release of Insulin-like Growth Factor-binding Protein 1 (IGFBP1) to Promote Angiogenesis* #MMPMID26245897
  • Nijaguna MB; Patil V; Urbach S; Shwetha SD; Sravani K; Hegde AS; Chandramouli BA; Arivazhagan A; Marin P; Santosh V; Somasundaram K
  • J Biol Chem 2015[Sep]; 290 (38): 23401-15 PMID26245897show ga
  • Background: Glioblastoma is highly aggressive and incurable by current treatment modalities.Results: MCSF is regulated by the SYK-PI3K-NF?B pathway in glioma and induces secretion of IGFBP1 from microglia to promote angiogenesis.Conclusion: Microglial IGFBP1 is a key mediator of MCSF-induced angiogenesis.Significance: IGFBP1 is a potential target for glioblastoma therapy.
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