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10.1021/acsmedchemlett.5b00215 http://scihub22266oqcxt.onion/10.1021/acsmedchemlett.5b00215 C4645242!4645242!26617966     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26617966&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2015 ; 6 (11): 1128-33 Nephropedia Template TP {{tp|p=26617966|t=2015. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment |pdf=|usr=}}{{26617966}} gab.com Text Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=26617966 #FOAvip Recent studies in adipose tissue, pancreas, muscle, and macrophages suggest that MAP4K4, a serine/threonine protein kinase may be a viable target for antidiabetic drugs. As part of the evaluation of MAP4K4 as a novel antidiabetic target, a tool compound, 16 (PF-6260933) and a lead 17 possessing excellent kinome selectivity and suitable properties were delivered to establish proof of concept in vivo. The medicinal chemistry effort that led to the discovery of these lead compounds is described herein together with in vivo pharmacokinetic properties and activity in a model of insulin resistance. Twit Text FOAVip Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=26617966 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26617966 #FOAvip English Wikipedia <ref>{{Cite pmid|26617966}}</ref> Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment #MMPMID26617966 Ammirati M; Bagley S; Bhattacharya SK; Buckbinder L; Carlo AA; Conrad R; Cortes C; Dow RL; Dowling M; El-Kattan A; Ford K; Guimarães CRW; Hepworth D; Jiao W; LaPerle J; Liu S; Londregan A; Loria P; Mathiowetz AM; Munchhof M; Orr STM; Petersen D; Price DA; Skoura A; Smith AC; Wang J ACS Med Chem Lett 2015[Nov]; 6 (11): 1128-33 PMID26617966show ga Recent studies in adipose tissue, pancreas, muscle, and macrophages suggest that MAP4K4, a serine/threonine protein kinase may be a viable target for antidiabetic drugs. As part of the evaluation of MAP4K4 as a novel antidiabetic target, a tool compound, 16 (PF-6260933) and a lead 17 possessing excellent kinome selectivity and suitable properties were delivered to establish proof of concept in vivo. The medicinal chemistry effort that led to the discovery of these lead compounds is described herein together with in vivo pharmacokinetic properties and activity in a model of insulin resistance. äDiscovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-(epmc).pdf DeepDyve Pubget Overpricing