Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26567707
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Sci+Rep
2015 ; 5
(ä): 16534
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Organ-wide 3D-imaging and topological analysis of the continuous microvascular
network in a murine lymph node
#MMPMID26567707
Kelch ID
; Bogle G
; Sands GB
; Phillips AR
; LeGrice IJ
; Dunbar PR
Sci Rep
2015[Nov]; 5
(ä): 16534
PMID26567707
show ga
Understanding of the microvasculature has previously been limited by the lack of
methods capable of capturing and modelling complete vascular networks. We used
novel imaging and computational techniques to establish the topology of the
entire blood vessel network of a murine lymph node, combining 63,706 confocal
images at 2??m pixel resolution to cover a volume of 3.88?mm(3). Detailed
measurements including the distribution of vessel diameters, branch counts, and
identification of voids were subsequently re-visualised in 3D revealing regional
specialisation within the network. By focussing on critical immune
microenvironments we quantified differences in their vascular topology. We
further developed a morphology-based approach to identify High Endothelial
Venules, key sites for lymphocyte extravasation. These data represent a
comprehensive and continuous blood vessel network of an entire organ and provide
benchmark measurements that will inform modelling of blood vessel networks as
well as enable comparison of vascular topology in different organs.