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Current Challenges in Glioblastoma: Intratumour Heterogeneity, Residual Disease,
and Models to Predict Disease Recurrence
#MMPMID26636033
Ellis HP
; Greenslade M
; Powell B
; Spiteri I
; Sottoriva A
; Kurian KM
Front Oncol
2015[]; 5
(?): 251
PMID26636033
show ga
Glioblastoma (GB) is the most common primary malignant brain tumor, and despite
the availability of chemotherapy and radiotherapy to combat the disease, overall
survival remains low with a high incidence of tumor recurrence. Technological
advances are continually improving our understanding of the disease, and in
particular, our knowledge of clonal evolution, intratumor heterogeneity, and
possible reservoirs of residual disease. These may inform how we approach
clinical treatment and recurrence in GB. Mathematical modeling (including neural
networks) and strategies such as multiple sampling during tumor resection and
genetic analysis of circulating cancer cells, may be of great future benefit to
help predict the nature of residual disease and resistance to standard and
molecular therapies in GB.