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10.3389/fonc.2015.00251

http://scihub22266oqcxt.onion/10.3389/fonc.2015.00251
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C4644939!4644939 !26636033
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suck abstract from ncbi

pmid26636033
      Front+Oncol 2015 ; 5 (?): 251
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  • Current Challenges in Glioblastoma: Intratumour Heterogeneity, Residual Disease, and Models to Predict Disease Recurrence #MMPMID26636033
  • Ellis HP ; Greenslade M ; Powell B ; Spiteri I ; Sottoriva A ; Kurian KM
  • Front Oncol 2015[]; 5 (?): 251 PMID26636033 show ga
  • Glioblastoma (GB) is the most common primary malignant brain tumor, and despite the availability of chemotherapy and radiotherapy to combat the disease, overall survival remains low with a high incidence of tumor recurrence. Technological advances are continually improving our understanding of the disease, and in particular, our knowledge of clonal evolution, intratumor heterogeneity, and possible reservoirs of residual disease. These may inform how we approach clinical treatment and recurrence in GB. Mathematical modeling (including neural networks) and strategies such as multiple sampling during tumor resection and genetic analysis of circulating cancer cells, may be of great future benefit to help predict the nature of residual disease and resistance to standard and molecular therapies in GB.
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